Modulation of the immune response by fetal kidney allografts

B. Dekel, J. H. Passwell, Y. Reisner

Research output: Contribution to journalReview articlepeer-review

Abstract

Fetal kidneys modulate the allogeneic immune response by a synergistic effect: first, fetal kidney tissue tropism is abrogated by the initial relative lack of adhesion molecules. Second, the reduced expression of major histocompatibility complex (MHC) determinants is less effective in inducing the alloantigen-primed T cell response, which in turn induces the downregulation of Th1 cytokines, β chemokines, and Fas Ligand, but spares protective Th2 cytokines, and leads to minimal induction of MHC and adhesion molecules on immature renal parenchymal elements. Thus, at the onset and during this altered rejection process, cellular recruitment to the fetal renal site is less prominent than to the adult renal tissue, and effector cells in the fetal graft are less activated.

Original languageEnglish
Pages (from-to)974-979
Number of pages6
JournalPediatric Nephrology
Volume13
Issue number9
DOIs
StatePublished - Nov 1999
Externally publishedYes

Keywords

  • Adhesion molecules
  • Cytokines
  • Fetal kidney
  • Immunogenicity
  • Major histocompatibility complex

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