TY - JOUR
T1 - Modulation of inflammatory pathways by the immune cholinergic system
AU - Nizri, Eran
AU - Brenner, Talma
N1 - Funding Information:
This work was supported in part by a grant from the Israel Ministry of Health Chief Scientist Fund.
PY - 2013/7
Y1 - 2013/7
N2 - Research done in the past years pointed to a novel function of cholinergic transmission. It has been shown that cholinergic transmission can modulate various aspects of the immune function, whether innate or adaptive. Cholinergic transmission affects immune cell proliferation, cytokine production, T helper differentiation and antigen presentation. Theses effects are mediated by cholinergic muscarinic and nicotinic receptors and other cholinergic components present in immune cells, such as acetylcholinesterase (AChE) and cholineacetyltransferase. The α7 nicotinic acetylcholine receptor was designated anti-inflammatory activity and has shown promise in pre-clinical models of inflammatory disorders. We herein describe the various components of the immune cholinergic system, and specifically the immune suppressive effects of α7 activation. This activation can be accomplished either by direct stimulation or indirectly, by inhibition of AChE. Thus, the presence of the immune cholinergic system can pave the way for novel immunomodulatory agents, or to the broadening of use of known cholinergic agents.
AB - Research done in the past years pointed to a novel function of cholinergic transmission. It has been shown that cholinergic transmission can modulate various aspects of the immune function, whether innate or adaptive. Cholinergic transmission affects immune cell proliferation, cytokine production, T helper differentiation and antigen presentation. Theses effects are mediated by cholinergic muscarinic and nicotinic receptors and other cholinergic components present in immune cells, such as acetylcholinesterase (AChE) and cholineacetyltransferase. The α7 nicotinic acetylcholine receptor was designated anti-inflammatory activity and has shown promise in pre-clinical models of inflammatory disorders. We herein describe the various components of the immune cholinergic system, and specifically the immune suppressive effects of α7 activation. This activation can be accomplished either by direct stimulation or indirectly, by inhibition of AChE. Thus, the presence of the immune cholinergic system can pave the way for novel immunomodulatory agents, or to the broadening of use of known cholinergic agents.
KW - Acetylcholinesterase inhibitors
KW - Multiple sclerosis
KW - Myasthenia gravis
KW - Neuroinflammation
KW - α7 nicotinic acetylcholine receptor
UR - http://www.scopus.com/inward/record.url?scp=84879198267&partnerID=8YFLogxK
U2 - 10.1007/s00726-011-1192-8
DO - 10.1007/s00726-011-1192-8
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C2 - 22194043
AN - SCOPUS:84879198267
SN - 0939-4451
VL - 45
SP - 73
EP - 85
JO - Amino Acids
JF - Amino Acids
IS - 1
ER -