Modulation of B and T cell subsets in mice treated with fractionated total lymphoid irradiation. II. Tolerance susceptibility of B cell subsets

Israel Zan‐Bar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Total lymphoid irradiation (TLI) results in long‐lasting changes in the characteristics of both T and B cells suggestive of arrested maturation. A characteristic feature of immature B cells is their high susceptibility to tolerance induction. This study examines the susceptibility to tolerance to bovine serum albumin (BSA) of TLI‐treated mice. Two experimental protocols were designed. In the first, tolerance to BSA was induced in TLI‐treated adult (BALB/c × C57BL/6)F1 mice, and the ability of B cells of those mice to respond to BSA was assessed in an adoptive transfer system. In the second experimental protocol, tolerance was induced in adoptive hosts reconstituted with purified B cells originating from TLI‐treated mice and with splenic T cells of normal, untreated mice. Results obtained in these two systems clearly demonstrated that splenic B cells of TLI‐treated mice are highly susceptible to tolerance induction. This high susceptibility of B cells is linked neither with the elevation of immature T cells nor with induced T suppressor cells which arise due to the long‐term malfunction of the thymus. Tolerance could be induced in TLI cells even 4 months after termination of the treatment. Thus, maturation processes of B cells in TLI‐treated mice are arrested for long periods of time.

Original languageEnglish
Pages (from-to)40-44
Number of pages5
JournalEuropean Journal of Immunology
Volume13
Issue number1
DOIs
StatePublished - 1983
Externally publishedYes

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