Modulation of a Shaker potassium A-channel by protein kinase C activation

Ofira Moran, Nathan Dascal, Ilana Lotan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Brain fast transient K??? channel (A channel) is known to be modulated by PKC activation. We studied, by two-electrode voltage clamp, the molecular mechanism of modulation by PKC activation of A-channels expressed in Xenopus oocytes from the Shaker H4 clone. The modulation is inhibitory affecting primarily the maximal conductance of the channels. A secondary effects is a small change in the voltage-dependence of activation and inactivation of the channel.

Original languageEnglish
Pages (from-to)256-260
Number of pages5
JournalFEBS Letters
Issue number2
StatePublished - 25 Feb 1991


FundersFunder number
Israel Academy of Sciences and Humanities


    • Activation
    • Inactivation
    • Modulation
    • Potassium channel
    • Protein kinase C


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