TY - JOUR
T1 - Modulation by opiates of small intestinal prostaglandin E2 and 3′, 5′ cyclic adenosine monophosphate levels and of indomethacin-induced ulceration in the rat
AU - Waisman, Yeheskel
AU - Marcus, Hedva
AU - Ligumski, Moshe
AU - Dinari, Gabriel
PY - 1991
Y1 - 1991
N2 - We studied the effect of parenteral morphine and naloxone administration on intestinal mucosal Prostaglandin E2 (PGE2) and 3′, 5′ cyclic adenosine monophosphate (cAMP) levels and on indomethacin-induced intestinal ulceration in the rat. Compared to the control group, morphine significantly decreased whereas naloxone markedly increased both PGE2 and cAMP mucosal levels, respectively. Morphine or naloxone alone did not cause mucosal injury. However, when given with indomethacin, morphine significantly potentiated the ulcerogenic effect of indomethacin while naloxone exerted a protective effect. These results suggest that opioid peptides may play a role in modulation of intestinal mucosal PGE2 and cAMP levels. In addition, enhancement of indomethacin-induced ulcer formation by morphine and amelioration by naloxone might be in part mediated through their effect on mucosal PGE2 and cAMP levels.
AB - We studied the effect of parenteral morphine and naloxone administration on intestinal mucosal Prostaglandin E2 (PGE2) and 3′, 5′ cyclic adenosine monophosphate (cAMP) levels and on indomethacin-induced intestinal ulceration in the rat. Compared to the control group, morphine significantly decreased whereas naloxone markedly increased both PGE2 and cAMP mucosal levels, respectively. Morphine or naloxone alone did not cause mucosal injury. However, when given with indomethacin, morphine significantly potentiated the ulcerogenic effect of indomethacin while naloxone exerted a protective effect. These results suggest that opioid peptides may play a role in modulation of intestinal mucosal PGE2 and cAMP levels. In addition, enhancement of indomethacin-induced ulcer formation by morphine and amelioration by naloxone might be in part mediated through their effect on mucosal PGE2 and cAMP levels.
UR - http://www.scopus.com/inward/record.url?scp=0025802803&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(91)90159-9
DO - 10.1016/0024-3205(91)90159-9
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AN - SCOPUS:0025802803
SN - 0024-3205
VL - 48
SP - 2035
EP - 2042
JO - Life Sciences
JF - Life Sciences
IS - 21
ER -