Modularity of CHIP/LDB transcription complexes regulates cell differentiation

Revital Bronstein, Daniel Segal

Research output: Contribution to journalArticlepeer-review

Abstract

Transcription is the first step through which the cell operates, via its repertoire of transcription complexes, to direct cellular functions and cellular identity by generating the cell-specific transcrip-tome. The modularity of the composition of constituents of these complexes allows the cell to delicately regulate its transcriptome. In a recent study we have examined the effects of reducing the levels of specific transcription co-factors on the function of two competing transcription complexes, namely CHIP-AP and CHIP-PNR, which regulate development of cells in the thorax of Drosophila. We found that changing the availability of these co-factors can shift the balance between these complexes leading to transition from utilization of CHIP-AP to CHIP-PNR. This is reflected in change in the expression profile of target genes, altering developmental cell fates. We propose that such a mechanism may operate in normal fly development. Transcription complexes analogous to CHIP-AP and CHIP-PNR exist in mammals and we discuss how such a shift in the balance between them may operate in normal mammalian development.

Original languageEnglish
Pages (from-to)200-205
Number of pages6
JournalFly
Volume5
Issue number3
DOIs
StatePublished - 2011

Keywords

  • Apterous
  • CHIP
  • CTBP
  • Gata
  • LHX
  • LMO
  • Ldb
  • Panier
  • SSDP
  • Transcription complex

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