Modular Access to Diverse Chemiluminescent Dioxetane-Luminophores through Convergent Synthesis

Samer Gnaim, Sachin Popat Gholap, Liang Ge, Sayantan Das, Sara Gutkin, Ori Green, Omri Shelef, Nir Hananya, Phil S. Baran, Doron Shabat*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Adamantyl-dioxetane luminophores are an important class of chemiluminescent molecular probes for diagnostics and imaging. We have developed a new efficient synthetic route for preparation of adamantyl-enolether as precursors for dioxetane chemiluminescent luminophores. The synthesis is convergent, using an unusual Stille cross-coupling reaction employing a stannane-enolether, to directly afford adamantyl-enolether. In a following simple step, the dioxetane is obtained by oxidation of the enolether precursor with singlet-oxygen. The scope of this synthetic route is broad since a large number of haloaryl substrates are either commercially available or easily accessible. Such a late-stage derivatization strategy simplifies the rapid exploration of novel luminogenic molecular structures in a library format and simplifies the synthesis of known dioxetane luminophores. We expect that this new synthetic strategy will be particularly useful in the design and synthesis of yet unexplored dioxetane chemiluminescent luminophores.

Original languageEnglish
Article numbere202202187
JournalAngewandte Chemie - International Edition
Volume61
Issue number22
DOIs
StatePublished - 23 May 2022

Keywords

  • Chemiluminescence
  • Cross-Coupling
  • Dioxetanes
  • Palladium
  • Synthetic Methods

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