Modified phospholipids as anti-inflammatory compounds

Erez Feige, Itzhak Mendel, Jacob George, Niva Yacov, Dror Harats

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of review: Oxidized phospholipids (OxPLs) are abundantly found at sites of inflammation and are considered to play an active role in the modulation of the immune response. Whereas most studies attributed a proinflammatory role to OxPLs, recent studies demonstrate that some products of phospholipid oxidation may in fact exhibit anti-inflammatory properties. This study summarizes the proinflammatory and anti-inflammatory properties of OxPLs and sheds light on the therapeutic potential of OxPL derivatives or analogs for treatment of chronic inflammatory disorders. Recent findings: OxPLs may inhibit activation of several Toll-like receptors and can epigenetically reduce the capacity of dendritic cells to function as mature, fully functional immunostimulatory cells. These data demonstrate that OxPLs can induce anti-inflammatory effects. Moreover, VB-201, an orally available synthetic phospholipid analog of the Lecinoxoid family, was found to attenuate inflammation in various preclinical animal models and is currently employed in a phase II clinical trial in psoriasis. Summary: Chemical or biological modifications of phospholipids yield various products, some of which may exhibit anti-inflammatory properties. Identification of such species and generation of more stable/potent anti-inflammatory OxPL variants may represent a novel approach for the treatment of immune-mediated diseases such as psoriasis, atherosclerosis, multiple sclerosis and rheumatoid arthritis.

Original languageEnglish
Pages (from-to)525-529
Number of pages5
JournalCurrent Opinion in Lipidology
Volume21
Issue number6
DOIs
StatePublished - Dec 2010
Externally publishedYes

Keywords

  • Lecinoxoids
  • OxPAPC
  • drug development
  • inflammation
  • oxidized phospholipids

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