Modified peptides from a water bloom of the cyanobacterium Nostoc sp.

Alexei Ploutno, Shmuel Carmeli*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Six new metabilites, nostopeptin BN920 (1), nostoginin BN741 (2), nostoginin BN578 (3), banyascyclamide A (4) banyascyclamide B (5) and banyascyclamide C (6), were isolated from the hydrophilic extract of a Nostoc sp. The planar structure of compounds 1-6 was determined by homonuclear and inverse-heteronuclear 2D NMR techniques as well as high-resolution mass spectrometry. The absolute configuration of the asymmetric centers was studied using Marfey's method for HPLC. Compound 1 inhibits the serine-protease chymotrypsin while compound 2 inhibits amino-proteases.

Original languageEnglish
Pages (from-to)9949-9957
Number of pages9
Issue number50
StatePublished - 9 Dec 2002


  • Cyanobacteria
  • Cyclichexapeptides
  • Nostoc
  • Protease inhibitors


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