Abstract
Six new metabilites, nostopeptin BN920 (1), nostoginin BN741 (2), nostoginin BN578 (3), banyascyclamide A (4) banyascyclamide B (5) and banyascyclamide C (6), were isolated from the hydrophilic extract of a Nostoc sp. The planar structure of compounds 1-6 was determined by homonuclear and inverse-heteronuclear 2D NMR techniques as well as high-resolution mass spectrometry. The absolute configuration of the asymmetric centers was studied using Marfey's method for HPLC. Compound 1 inhibits the serine-protease chymotrypsin while compound 2 inhibits amino-proteases.
Original language | English |
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Pages (from-to) | 9949-9957 |
Number of pages | 9 |
Journal | Tetrahedron |
Volume | 58 |
Issue number | 50 |
DOIs | |
State | Published - 9 Dec 2002 |
Keywords
- Cyanobacteria
- Cyclichexapeptides
- Nostoc
- Protease inhibitors