Modelling the immune system response to epithelial wound infections

F. J. Vermolen*, E. C.M.M. Arkesteijn, A. Gefen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In this paper, a cell-colony based formalism for the healing of superficial wounds is presented. The paper incorporates the migration, proliferation, and death of constituent cells, in the context of wound healing. The present study considers wound healing under ischemic conditions where a bacterial infection develops, which impairs the motility of the constituent cells. In this work, the performance of the immune response system is incorporated in the sense that migrating leukocyte are modelled which engulf the infectious pathogens. The model is based on both deterministic and stochastic principles. Simulation results are discussed in a biological context.

Original languageEnglish
Pages (from-to)158-169
Number of pages12
JournalJournal of Theoretical Biology
Volume393
DOIs
StatePublished - 21 Mar 2016

Keywords

  • Cell-based modelling
  • Fundamental solutions
  • Immune system response

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