TY - JOUR
T1 - Modelling the immune system response to epithelial wound infections
AU - Vermolen, F. J.
AU - Arkesteijn, E. C.M.M.
AU - Gefen, A.
N1 - Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/3/21
Y1 - 2016/3/21
N2 - In this paper, a cell-colony based formalism for the healing of superficial wounds is presented. The paper incorporates the migration, proliferation, and death of constituent cells, in the context of wound healing. The present study considers wound healing under ischemic conditions where a bacterial infection develops, which impairs the motility of the constituent cells. In this work, the performance of the immune response system is incorporated in the sense that migrating leukocyte are modelled which engulf the infectious pathogens. The model is based on both deterministic and stochastic principles. Simulation results are discussed in a biological context.
AB - In this paper, a cell-colony based formalism for the healing of superficial wounds is presented. The paper incorporates the migration, proliferation, and death of constituent cells, in the context of wound healing. The present study considers wound healing under ischemic conditions where a bacterial infection develops, which impairs the motility of the constituent cells. In this work, the performance of the immune response system is incorporated in the sense that migrating leukocyte are modelled which engulf the infectious pathogens. The model is based on both deterministic and stochastic principles. Simulation results are discussed in a biological context.
KW - Cell-based modelling
KW - Fundamental solutions
KW - Immune system response
UR - http://www.scopus.com/inward/record.url?scp=84955437814&partnerID=8YFLogxK
U2 - 10.1016/j.jtbi.2015.12.030
DO - 10.1016/j.jtbi.2015.12.030
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AN - SCOPUS:84955437814
SN - 0022-5193
VL - 393
SP - 158
EP - 169
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
ER -