Modelling and analysis of gene regulatory networks

Guy Karlebach, Ron Shamir

Research output: Contribution to journalReview articlepeer-review


Gene regulatory networks have an important role in every process of life, including cell differentiation, metabolism, the cell cycle and signal transduction. By understanding the dynamics of these networks we can shed light on the mechanisms of diseases that occur when these cellular processes are dysregulated. Accurate prediction of the behaviour of regulatory networks will also speed up biotechnological projects, as such predictions are quicker and cheaper than lab experiments. Computational methods, both for supporting the development of network models and for the analysis of their functionality, have already proved to be a valuable research tool.

Original languageEnglish
Pages (from-to)770-780
Number of pages11
JournalNature Reviews Molecular Cell Biology
Issue number10
StatePublished - Oct 2008


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