Modeling three-dimensional genomic organization in evolution and pathogenesis

Alon Diament; Tamir Tuller

doi:10.1016/j.semcdb.2018.07.008

Modeling three-dimensional genomic organization in evolution and pathogenesis

Alon Diament, Tamir Tuller^*

^*Corresponding author for this work

Department of Bio-Medical Engineering

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The regulation of gene expression is mediated via the complex three-dimensional (3D) conformation of the genetic material and its interactions with various intracellular factors. Various experimental and computational approaches have been developed in recent years for understating the relation between the 3D conformation of the genome and the phenotypes of cells in normal condition and diseases. In this review, we will discuss novel approaches for analyzing and modeling the 3D genomic conformation, focusing on deciphering disease-causing mutations that affect gene expression. We conclude that as this is a very challenging mission, an important direction should involve the comparative analysis of various 3D models from various organisms or cells.

Original language	English
Pages (from-to)	78-93
Number of pages	16
Journal	Seminars in Cell and Developmental Biology
Volume	90
DOIs	https://doi.org/10.1016/j.semcdb.2018.07.008
State	Published - Jun 2019

Funding

Funders	Funder number
Azrieli Foundation

Keywords

Comparative genomics
Computational models
Disease-causing mutations
Gene expression
Three-dimensional genomic organization

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10.1016/j.semcdb.2018.07.008

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abstract = "The regulation of gene expression is mediated via the complex three-dimensional (3D) conformation of the genetic material and its interactions with various intracellular factors. Various experimental and computational approaches have been developed in recent years for understating the relation between the 3D conformation of the genome and the phenotypes of cells in normal condition and diseases. In this review, we will discuss novel approaches for analyzing and modeling the 3D genomic conformation, focusing on deciphering disease-causing mutations that affect gene expression. We conclude that as this is a very challenging mission, an important direction should involve the comparative analysis of various 3D models from various organisms or cells.",

keywords = "Comparative genomics, Computational models, Disease-causing mutations, Gene expression, Three-dimensional genomic organization",

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KW - Computational models

KW - Disease-causing mutations

KW - Gene expression

KW - Three-dimensional genomic organization

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Modeling three-dimensional genomic organization in evolution and pathogenesis

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Keywords

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