Modeling membrane shaping by proteins: Focus on EHD2 and N-BAR domains

Felix Campelo, Gur Fabrikant, Harvey T. McMahon, Michael M. Kozlov*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Cellular membranes are highly dynamic, undergoing both persistent and dynamic shape changes driven by specialized proteins. The observed membrane shaping can be simple deformations of existing shapes or membrane remodeling involving fission or fusion. Here we describe several mechanistic principles by which membrane shaping proteins act. We especially consider models for membrane bending and fission by EHD2 proteins and membrane bending by N-BAR domains. There are major challenges ahead to understand the general principles by which diverse membrane bending proteins act and to understand how some proteins appear to span multiple modes of action from driving curvature to inducing membrane remodeling.

Original languageEnglish
Pages (from-to)1830-1839
Number of pages10
JournalFEBS Letters
Volume584
Issue number9
DOIs
StatePublished - May 2010

Keywords

  • EHD2
  • Membrane curvature
  • Membrane fission
  • Membrane fusion
  • Membrane shaping
  • N-BAR

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