Modeling brain energy metabolism and function: A multiparametric monitoring approach

Larisa Vatov, Ziv Kizner, Eytan Ruppin, Sigal Meilin, Tamar Manor, Avraham Mayevsky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Mathematical modeling of brain function is an important tool needed for a better understanding of experimental results and clinical situations. In the present study, we are constructing and testing a mathematical model capable of simulating changes in brain energy metabolism that develop in real time under various pathophysiological conditions. The model incorporates the following parameters: cerebral blood flow, partial oxygen pressure, mitochondrial NADH redox state, and extracellular potassium. Accordingly, all the model variables are only time dependent ('point-model' approach). Numerical runs demonstrate the ability of the model to mimic pathological conditions, such as complete and partial ischemia, cortical spreading depression under normoxic and partial ischemic conditions. They also show that, when properly tuned, a model of this type permits the monitoring of only one or two crucial variables and the computation of the remaining variables in real time during clinical or experimental procedures.

Original languageEnglish
Pages (from-to)275-291
Number of pages17
JournalBulletin of Mathematical Biology
Volume68
Issue number2
DOIs
StatePublished - Feb 2006

Keywords

  • Brain energy metabolism
  • Cerebral ischemia
  • Cortical spreading depression
  • Mathematical model
  • Mitochondrial function
  • NADH redox state

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