Model selection methodology for inter-laboratory standardisation of antibody titres

George Kafatos, Nick Andrews, Anthony Nardone, J. Backhouse, L. Gilbert, S. Broodhaers, P. Van Damme, L. De Cock, H. Theeten, R. Vranckx, N. Gatcheva, Z. Mihneva, V. Voynova, C. Hadjianastassiou, M. Zarvou, B. Kriz, V. Nemecek, N. Andrews, W. J. Edmunds, N. GayD. Gelb, L. Hesketh, G. Kafatos, E. Miller, P. Morgan-Capner, A. Nardone, R. Pebody, I. Davidkin, R. M. Ölander, M. Valle, W. Hellenbrand, W. Thierfelder, A. Tischer, C. Anastassopoulou, A. Hatzakis, A. Tsakris, K. Bartha, I. Karacs, I. Lontai, M. Melles, M. Carton, L. Jones, D. O'Flanagan, Y. Aboudy, D. Cohen, M. Green, E. Marva, Z. Smetana, G. Gabutti, A. Giammanco, G. Icardi, C. Rota, S. Salmaso, C. Von Hunolstein, J. Bebris, A. Duks, J. Perevoscikovs, I. Rezebergs, I. Selga, I. Velicko, V. Baksenas, A. Griskevicius, J. Suracienne, J. Mossong, F. Schneider, A. Amato-Gauci, C. Barbara, G. Berbers, H. De Melker, V. Alexandrescu, D. Butur, E. Lupulesku, A. Pistol, R. Viorica, B. Černáková, J. Lančová, E. Máderová, I. Rovný, M. Slačiková, A. Kraigher, K. Prosenc, M. V.M. De Aragón, F. De Ory, J. M. Echevarria, R. M. Carlsson, K. Johansen, E. Reizenstein

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the European Sero-Epidemiology Network 2 (ESEN2) is to compare standardised serological results of vaccine preventable diseases across Europe. In order to adjust for laboratory and assay differences, the participant laboratories tested a standardisation panel for each disease and the results were plotted against those of a reference centre in order to obtain standardisation equations. We describe an algorithm for obtaining these equations which took into account outliers, censored data and model selection, and needed to be robust due to the variety of assays and diseases under investigation. If the standardisation equations explained sufficient variability, these were used to convert each country's main serum bank results to a common unitage, thereby allowing international comparisons to be made.

Original languageEnglish
Pages (from-to)5022-5027
Number of pages6
JournalVaccine
Volume23
Issue number42
DOIs
StatePublished - 10 Oct 2005
Externally publishedYes

Keywords

  • Assay comparison
  • Sero-epidemiology
  • Standardisation equation

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