Model selection methodology for inter-laboratory standardisation of antibody titres

George Kafatos; Nick Andrews; Anthony Nardone; J. Backhouse; L. Gilbert; S. Broodhaers; P. Van Damme; L. De Cock; H. Theeten; R. Vranckx; N. Gatcheva; Z. Mihneva; V. Voynova; C. Hadjianastassiou; M. Zarvou; B. Kriz; V. Nemecek; N. Andrews; W. J. Edmunds; N. Gay; D. Gelb; L. Hesketh; G. Kafatos; E. Miller; P. Morgan-Capner; A. Nardone; R. Pebody; I. Davidkin; R. M. Ölander; M. Valle; W. Hellenbrand; W. Thierfelder; A. Tischer; C. Anastassopoulou; A. Hatzakis; A. Tsakris; K. Bartha; I. Karacs; I. Lontai; M. Melles; M. Carton; L. Jones; D. O'Flanagan; Y. Aboudy; D. Cohen; M. Green; E. Marva; Z. Smetana; G. Gabutti; A. Giammanco; G. Icardi; C. Rota; S. Salmaso; C. Von Hunolstein; J. Bebris; A. Duks; J. Perevoscikovs; I. Rezebergs; I. Selga; I. Velicko; V. Baksenas; A. Griskevicius; J. Suracienne; J. Mossong; F. Schneider; A. Amato-Gauci; C. Barbara; G. Berbers; H. De Melker; V. Alexandrescu; D. Butur; E. Lupulesku; A. Pistol; R. Viorica; B. Černáková; J. Lančová; E. Máderová; I. Rovný; M. Slačiková; A. Kraigher; K. Prosenc; M. V.M. De Aragón; F. De Ory; J. M. Echevarria; R. M. Carlsson; K. Johansen; E. Reizenstein

doi:10.1016/j.vaccine.2005.05.030

Model selection methodology for inter-laboratory standardisation of antibody titres

George Kafatos^*, Nick Andrews, Anthony Nardone, J. Backhouse, L. Gilbert, S. Broodhaers, P. Van Damme, L. De Cock, H. Theeten, R. Vranckx, N. Gatcheva, Z. Mihneva, V. Voynova, C. Hadjianastassiou, M. Zarvou, B. Kriz, V. Nemecek, N. Andrews, W. J. Edmunds, N. GayD. Gelb, L. Hesketh, G. Kafatos^*, E. Miller, P. Morgan-Capner, A. Nardone, R. Pebody, I. Davidkin, R. M. Ölander, M. Valle, W. Hellenbrand, W. Thierfelder, A. Tischer, C. Anastassopoulou, A. Hatzakis, A. Tsakris, K. Bartha, I. Karacs, I. Lontai, M. Melles, M. Carton, L. Jones, D. O'Flanagan, Y. Aboudy, D. Cohen, M. Green, E. Marva, Z. Smetana, G. Gabutti, A. Giammanco, G. Icardi, C. Rota, S. Salmaso, C. Von Hunolstein, J. Bebris, A. Duks, J. Perevoscikovs, I. Rezebergs, I. Selga, I. Velicko, V. Baksenas, A. Griskevicius, J. Suracienne, J. Mossong, F. Schneider, A. Amato-Gauci, C. Barbara, G. Berbers, H. De Melker, V. Alexandrescu, D. Butur, E. Lupulesku, A. Pistol, R. Viorica, B. Černáková, J. Lančová, E. Máderová, I. Rovný, M. Slačiková, A. Kraigher, K. Prosenc, M. V.M. De Aragón, F. De Ory, J. M. Echevarria, R. M. Carlsson, K. Johansen, E. Reizenstein

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

The aim of the European Sero-Epidemiology Network 2 (ESEN2) is to compare standardised serological results of vaccine preventable diseases across Europe. In order to adjust for laboratory and assay differences, the participant laboratories tested a standardisation panel for each disease and the results were plotted against those of a reference centre in order to obtain standardisation equations. We describe an algorithm for obtaining these equations which took into account outliers, censored data and model selection, and needed to be robust due to the variety of assays and diseases under investigation. If the standardisation equations explained sufficient variability, these were used to convert each country's main serum bank results to a common unitage, thereby allowing international comparisons to be made.

Original language	English
Pages (from-to)	5022-5027
Number of pages	6
Journal	Vaccine
Volume	23
Issue number	42
DOIs	https://doi.org/10.1016/j.vaccine.2005.05.030
State	Published - 10 Oct 2005
Externally published	Yes

Keywords

Assay comparison
Sero-epidemiology
Standardisation equation

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10.1016/j.vaccine.2005.05.030

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Kafatos, G., Andrews, N., Nardone, A., Backhouse, J., Gilbert, L., Broodhaers, S., Van Damme, P., De Cock, L., Theeten, H., Vranckx, R., Gatcheva, N., Mihneva, Z., Voynova, V., Hadjianastassiou, C., Zarvou, M., Kriz, B., Nemecek, V., Andrews, N., Edmunds, W. J., ... Reizenstein, E. (2005). Model selection methodology for inter-laboratory standardisation of antibody titres. Vaccine, 23(42), 5022-5027. https://doi.org/10.1016/j.vaccine.2005.05.030

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title = "Model selection methodology for inter-laboratory standardisation of antibody titres",

abstract = "The aim of the European Sero-Epidemiology Network 2 (ESEN2) is to compare standardised serological results of vaccine preventable diseases across Europe. In order to adjust for laboratory and assay differences, the participant laboratories tested a standardisation panel for each disease and the results were plotted against those of a reference centre in order to obtain standardisation equations. We describe an algorithm for obtaining these equations which took into account outliers, censored data and model selection, and needed to be robust due to the variety of assays and diseases under investigation. If the standardisation equations explained sufficient variability, these were used to convert each country's main serum bank results to a common unitage, thereby allowing international comparisons to be made.",

keywords = "Assay comparison, Sero-epidemiology, Standardisation equation",

author = "George Kafatos and Nick Andrews and Anthony Nardone and J. Backhouse and L. Gilbert and S. Broodhaers and {Van Damme}, P. and {De Cock}, L. and H. Theeten and R. Vranckx and N. Gatcheva and Z. Mihneva and V. Voynova and C. Hadjianastassiou and M. Zarvou and B. Kriz and V. Nemecek and N. Andrews and Edmunds, {W. J.} and N. Gay and D. Gelb and L. Hesketh and G. Kafatos and E. Miller and P. Morgan-Capner and A. Nardone and R. Pebody and I. Davidkin and {\"O}lander, {R. M.} and M. Valle and W. Hellenbrand and W. Thierfelder and A. Tischer and C. Anastassopoulou and A. Hatzakis and A. Tsakris and K. Bartha and I. Karacs and I. Lontai and M. Melles and M. Carton and L. Jones and D. O'Flanagan and Y. Aboudy and D. Cohen and M. Green and E. Marva and Z. Smetana and G. Gabutti and A. Giammanco and G. Icardi and C. Rota and S. Salmaso and {Von Hunolstein}, C. and J. Bebris and A. Duks and J. Perevoscikovs and I. Rezebergs and I. Selga and I. Velicko and V. Baksenas and A. Griskevicius and J. Suracienne and J. Mossong and F. Schneider and A. Amato-Gauci and C. Barbara and G. Berbers and {De Melker}, H. and V. Alexandrescu and D. Butur and E. Lupulesku and A. Pistol and R. Viorica and B. {\v C}ern{\'a}kov{\'a} and J. Lan{\v c}ov{\'a} and E. M{\'a}derov{\'a} and I. Rovn{\'y} and M. Sla{\v c}ikov{\'a} and A. Kraigher and K. Prosenc and {De Arag{\'o}n}, {M. V.M.} and {De Ory}, F. and Echevarria, {J. M.} and Carlsson, {R. M.} and K. Johansen and E. Reizenstein",

year = "2005",

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doi = "10.1016/j.vaccine.2005.05.030",

language = "אנגלית",

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journal = "Vaccine",

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number = "42",

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Kafatos, G, Andrews, N, Nardone, A, Backhouse, J, Gilbert, L, Broodhaers, S, Van Damme, P, De Cock, L, Theeten, H, Vranckx, R, Gatcheva, N, Mihneva, Z, Voynova, V, Hadjianastassiou, C, Zarvou, M, Kriz, B, Nemecek, V, Andrews, N, Edmunds, WJ, Gay, N, Gelb, D, Hesketh, L, Kafatos, G, Miller, E, Morgan-Capner, P, Nardone, A, Pebody, R, Davidkin, I, Ölander, RM, Valle, M, Hellenbrand, W, Thierfelder, W, Tischer, A, Anastassopoulou, C, Hatzakis, A, Tsakris, A, Bartha, K, Karacs, I, Lontai, I, Melles, M, Carton, M, Jones, L, O'Flanagan, D, Aboudy, Y, Cohen, D, Green, M, Marva, E, Smetana, Z, Gabutti, G, Giammanco, A, Icardi, G, Rota, C, Salmaso, S, Von Hunolstein, C, Bebris, J, Duks, A, Perevoscikovs, J, Rezebergs, I, Selga, I, Velicko, I, Baksenas, V, Griskevicius, A, Suracienne, J, Mossong, J, Schneider, F, Amato-Gauci, A, Barbara, C, Berbers, G, De Melker, H, Alexandrescu, V, Butur, D, Lupulesku, E, Pistol, A, Viorica, R, Černáková, B, Lančová, J, Máderová, E, Rovný, I, Slačiková, M, Kraigher, A, Prosenc, K, De Aragón, MVM, De Ory, F, Echevarria, JM, Carlsson, RM, Johansen, K & Reizenstein, E 2005, 'Model selection methodology for inter-laboratory standardisation of antibody titres', Vaccine, vol. 23, no. 42, pp. 5022-5027. https://doi.org/10.1016/j.vaccine.2005.05.030

TY - JOUR

T1 - Model selection methodology for inter-laboratory standardisation of antibody titres

AU - Kafatos, George

AU - Andrews, Nick

AU - Nardone, Anthony

AU - Backhouse, J.

AU - Gilbert, L.

AU - Broodhaers, S.

AU - Van Damme, P.

AU - De Cock, L.

AU - Theeten, H.

AU - Vranckx, R.

AU - Gatcheva, N.

AU - Mihneva, Z.

AU - Voynova, V.

AU - Hadjianastassiou, C.

AU - Zarvou, M.

AU - Kriz, B.

AU - Nemecek, V.

AU - Andrews, N.

AU - Edmunds, W. J.

AU - Gay, N.

AU - Gelb, D.

AU - Hesketh, L.

AU - Kafatos, G.

AU - Miller, E.

AU - Morgan-Capner, P.

AU - Nardone, A.

AU - Pebody, R.

AU - Davidkin, I.

AU - Ölander, R. M.

AU - Valle, M.

AU - Hellenbrand, W.

AU - Thierfelder, W.

AU - Tischer, A.

AU - Anastassopoulou, C.

AU - Hatzakis, A.

AU - Tsakris, A.

AU - Bartha, K.

AU - Karacs, I.

AU - Lontai, I.

AU - Melles, M.

AU - Carton, M.

AU - Jones, L.

AU - O'Flanagan, D.

AU - Aboudy, Y.

AU - Cohen, D.

AU - Green, M.

AU - Marva, E.

AU - Smetana, Z.

AU - Gabutti, G.

AU - Giammanco, A.

AU - Icardi, G.

AU - Rota, C.

AU - Salmaso, S.

AU - Von Hunolstein, C.

AU - Bebris, J.

AU - Duks, A.

AU - Perevoscikovs, J.

AU - Rezebergs, I.

AU - Selga, I.

AU - Velicko, I.

AU - Baksenas, V.

AU - Griskevicius, A.

AU - Suracienne, J.

AU - Mossong, J.

AU - Schneider, F.

AU - Amato-Gauci, A.

AU - Barbara, C.

AU - Berbers, G.

AU - De Melker, H.

AU - Alexandrescu, V.

AU - Butur, D.

AU - Lupulesku, E.

AU - Pistol, A.

AU - Viorica, R.

AU - Černáková, B.

AU - Lančová, J.

AU - Máderová, E.

AU - Rovný, I.

AU - Slačiková, M.

AU - Kraigher, A.

AU - Prosenc, K.

AU - De Aragón, M. V.M.

AU - De Ory, F.

AU - Echevarria, J. M.

AU - Carlsson, R. M.

AU - Johansen, K.

AU - Reizenstein, E.

PY - 2005/10/10

Y1 - 2005/10/10

N2 - The aim of the European Sero-Epidemiology Network 2 (ESEN2) is to compare standardised serological results of vaccine preventable diseases across Europe. In order to adjust for laboratory and assay differences, the participant laboratories tested a standardisation panel for each disease and the results were plotted against those of a reference centre in order to obtain standardisation equations. We describe an algorithm for obtaining these equations which took into account outliers, censored data and model selection, and needed to be robust due to the variety of assays and diseases under investigation. If the standardisation equations explained sufficient variability, these were used to convert each country's main serum bank results to a common unitage, thereby allowing international comparisons to be made.

AB - The aim of the European Sero-Epidemiology Network 2 (ESEN2) is to compare standardised serological results of vaccine preventable diseases across Europe. In order to adjust for laboratory and assay differences, the participant laboratories tested a standardisation panel for each disease and the results were plotted against those of a reference centre in order to obtain standardisation equations. We describe an algorithm for obtaining these equations which took into account outliers, censored data and model selection, and needed to be robust due to the variety of assays and diseases under investigation. If the standardisation equations explained sufficient variability, these were used to convert each country's main serum bank results to a common unitage, thereby allowing international comparisons to be made.

KW - Assay comparison

KW - Sero-epidemiology

KW - Standardisation equation

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U2 - 10.1016/j.vaccine.2005.05.030

DO - 10.1016/j.vaccine.2005.05.030

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C2 - 16002191

AN - SCOPUS:24644503974

SN - 0264-410X

VL - 23

SP - 5022

EP - 5027

JO - Vaccine

JF - Vaccine

IS - 42

ER -

Model selection methodology for inter-laboratory standardisation of antibody titres

Abstract

Keywords

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