TY - JOUR
T1 - Mode of ventilation during cardiopulmonary bypass does not affect immediate postbypass oxygenation in pediatric cardiac patients
AU - Sasson, Lior
AU - Sherman, Alexander
AU - Ezri, Tiberiu
AU - Houri, Sion
AU - Ghilad, Eli
AU - Cohen, Ilan
AU - Evron, Shmuel
PY - 2007/9
Y1 - 2007/9
N2 - Study Objective: To investigate the impact of different modes of ventilation during cardiopulmonary bypass (CPB) on immediate postbypass oxygenation in pediatric cardiac surgery. Design: Prospective, randomized clinical trial. Setting: University hospital. Patients: 50 pediatric patients (18 girls, 32 boys), aged 4 months to 15 years, undergoing elective repair of congenital heart disease. Interventions: Patients were randomized to receive one of 5 modes of ventilation during bypass. Groups 1 and 2 received high-frequency/low-volume ventilation with 100% (group 1) or 21% oxygen (group 2). Groups 3 and 4 received continuous positive airway pressure of 5 cm H2O with 100% (group 3) or 21% oxygen (group 4); and in group 5, each patient's airway was disconnected from the ventilator (passive deflation). Measurements: Blood gas analysis and spirometry data were recorded 5 minutes before chest opening, 5 minutes before inducing bypass, 5 minutes after weaning from bypass, and 5 minutes after chest closure. Main Results: There were no differences in Pao2 values among the 5 groups studied and at the different time points. Lung compliance was higher 5 minutes before bypass in group 1 versus group 5 (34 ± 13 mL/cm H2O vs 20 ± 9 mL/cm H2O; P = 0.048). Conclusions: Mode of ventilation during CPB did not affect immediate postbypass oxygenation.
AB - Study Objective: To investigate the impact of different modes of ventilation during cardiopulmonary bypass (CPB) on immediate postbypass oxygenation in pediatric cardiac surgery. Design: Prospective, randomized clinical trial. Setting: University hospital. Patients: 50 pediatric patients (18 girls, 32 boys), aged 4 months to 15 years, undergoing elective repair of congenital heart disease. Interventions: Patients were randomized to receive one of 5 modes of ventilation during bypass. Groups 1 and 2 received high-frequency/low-volume ventilation with 100% (group 1) or 21% oxygen (group 2). Groups 3 and 4 received continuous positive airway pressure of 5 cm H2O with 100% (group 3) or 21% oxygen (group 4); and in group 5, each patient's airway was disconnected from the ventilator (passive deflation). Measurements: Blood gas analysis and spirometry data were recorded 5 minutes before chest opening, 5 minutes before inducing bypass, 5 minutes after weaning from bypass, and 5 minutes after chest closure. Main Results: There were no differences in Pao2 values among the 5 groups studied and at the different time points. Lung compliance was higher 5 minutes before bypass in group 1 versus group 5 (34 ± 13 mL/cm H2O vs 20 ± 9 mL/cm H2O; P = 0.048). Conclusions: Mode of ventilation during CPB did not affect immediate postbypass oxygenation.
KW - Cardiopulmonary bypass
KW - Pediatric cardiac surgery
KW - Postbypass oxygenation
KW - Ventilation
UR - http://www.scopus.com/inward/record.url?scp=35448957712&partnerID=8YFLogxK
U2 - 10.1016/j.jclinane.2007.03.007
DO - 10.1016/j.jclinane.2007.03.007
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:35448957712
SN - 0952-8180
VL - 19
SP - 429
EP - 433
JO - Journal of Clinical Anesthesia
JF - Journal of Clinical Anesthesia
IS - 6
ER -
