Mode of regulation of immunoglobulin μ- and δ-chain expression varies during B-lymphocyte maturation

Elizabeth L. Mather, Kathleen J. Nelson, Joseph Haimovich, Robert P. Perry

Research output: Contribution to journalArticlepeer-review

Abstract

The transcription, processing, and accumulation of μ and δ mRNA was studied in several cell lines representing different stages of B-lymphocyte maturation. Our results indicate that the relative content of μ and δ mRNA is the major determinant of the IgM versus IgM + IgD phenotype and that the production of δ mRNA is regulated at distinctly different levels of gene expression in early and later developmental stages. In B cell lymphomas typical of early stages, transcription extends over the entire 25 kb of the μ-δ locus and the relative content of μ and δ mRNA is determined at the level of mRNA processing. In contrast, in cells typical of mature IgM secretors, transcription is terminated abruptly between the μ and δ genes, precluding the production of δ mRNA. We propose a model that accounts for qualitative and quantitative changes in μ-δ expression in the developing B lymphocyte.

Original languageEnglish
Pages (from-to)329-338
Number of pages10
JournalCell
Volume36
Issue number2
DOIs
StatePublished - Feb 1984
Externally publishedYes

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