Mn(ii)-catalysed alkylation of methylene ketones with alcohols: Direct access to functionalised branched products

Lalit Mohan Kabadwal, Jagadish Das, Debasis Banerjee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Herein an operationally simple alkylation of methylene ketones with primary alcohols is reported. Use of an inexpensive and earth abundant Mn/1,10-phenanthroline system enables direct access to a series of functionalised branched ketones including one-pot sequential double alkylation and Alzheimer's drug donepezil. Preliminary mechanistic investigation, determination of the rate and order of reactions and deuterium labeling experiments support the participation of the hydrogen-borrowing strategy for the ketone alkylation.

Original languageEnglish
Pages (from-to)14069-14072
Number of pages4
JournalChemical Communications
Volume54
Issue number100
DOIs
StatePublished - 2018
Externally publishedYes

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