Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility

Boaz Styr, Nir Gonen, Daniel Zarhin, Antonella Ruggiero, Refaela Atsmon, Neta Gazit, Gabriella Braun, Samuel Frere, Irena Vertkin, Ilana Shapira, Michal Harel, Leore R. Heim, Maxim Katsenelson, Ohad Rechnitz, Saja Fadila, Dori Derdikman, Moran Rubinstein, Tamar Geiger, Eytan Ruppin, Inna Slutsky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Firing rate set-point regulation has puzzled researchers for decades. Our findings show that mitochondrial DHODH meets the criteria of a bone fide regulator of activity set points and suggest lowering firing set point as a new strategy to treat epilepsy.

Original languageEnglish
Pages (from-to)1009-1024.e8
Issue number5
StatePublished - 5 Jun 2019


FundersFunder number
National Cancer InstituteZIABC011802
European Research Council724866
Rosetrees Trust
Ministry of Science, Technology and Space
Israel Science Foundation1849/17, 1663/18
Porter School of Environmental Studies, Tel Aviv University
Azrieli Foundation


    • Dravet syndrome
    • calcium
    • dihydroorotate dehydrogenase
    • epilepsy
    • firing rate
    • hippocampus
    • homeostasis
    • mitochondria
    • neuronal metabolism
    • set point


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