Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility

Boaz Styr, Nir Gonen, Daniel Zarhin, Antonella Ruggiero, Refaela Atsmon, Neta Gazit, Gabriella Braun, Samuel Frere, Irena Vertkin, Ilana Shapira, Michal Harel, Leore R. Heim, Maxim Katsenelson, Ohad Rechnitz, Saja Fadila, Dori Derdikman, Moran Rubinstein, Tamar Geiger, Eytan Ruppin, Inna Slutsky

Research output: Contribution to journalArticlepeer-review

Abstract

Firing rate set-point regulation has puzzled researchers for decades. Our findings show that mitochondrial DHODH meets the criteria of a bone fide regulator of activity set points and suggest lowering firing set point as a new strategy to treat epilepsy.

Original languageEnglish
Pages (from-to)1009-1024.e8
JournalNeuron
Volume102
Issue number5
DOIs
StatePublished - 5 Jun 2019

Keywords

  • Dravet syndrome
  • calcium
  • dihydroorotate dehydrogenase
  • epilepsy
  • firing rate
  • hippocampus
  • homeostasis
  • mitochondria
  • neuronal metabolism
  • set point

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