Mitochondrial matrix-localized p53 participates in degradation of mitochondrial RNAs

Yael Friedman, Amnon Hizi, Dror Avni, Mary Bakhanashvili*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Mitochondrial RNA degradation plays an important role in maintenance of the mitochondria genetic integrity. Mitochondrial localization of p53 was observed in non-stressed and stressed cells. p53, as an RNA-binding protein, exerts 3′→5′ exoribonuclease activity. The data suggest that in non-stressed cells, mitochondrial matrix-localized p53, with exoribonuclease activity, may play a housekeeping positive role. p53, through restriction the formation of new RNA/DNA hybrid and processing R-loop, might serve as mitochondrial R-loop suppressor. Conversely, stress-induced matrix-p53 decreases the amount of mitochondrial single-stranded RNA transcripts (including polyA- and non-polyA RNAs), thereby leading to the decline in the amount of mitochondria-encoded oxidative phosphorylation components.

Original languageEnglish
Pages (from-to)200-212
Number of pages13
StatePublished - May 2021


FundersFunder number
Israel Cancer Association USA20190069


    • Degradation
    • Exonuclease
    • Mitochondrial RNA
    • P53
    • R-loop


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