@article{a9ea3c50ae904bc0b907fb998eddf2bc,
title = "Mitochondrial matrix-localized p53 participates in degradation of mitochondrial RNAs",
abstract = "Mitochondrial RNA degradation plays an important role in maintenance of the mitochondria genetic integrity. Mitochondrial localization of p53 was observed in non-stressed and stressed cells. p53, as an RNA-binding protein, exerts 3′→5′ exoribonuclease activity. The data suggest that in non-stressed cells, mitochondrial matrix-localized p53, with exoribonuclease activity, may play a housekeeping positive role. p53, through restriction the formation of new RNA/DNA hybrid and processing R-loop, might serve as mitochondrial R-loop suppressor. Conversely, stress-induced matrix-p53 decreases the amount of mitochondrial single-stranded RNA transcripts (including polyA- and non-polyA RNAs), thereby leading to the decline in the amount of mitochondria-encoded oxidative phosphorylation components.",
keywords = "Degradation, Exonuclease, Mitochondrial RNA, P53, R-loop",
author = "Yael Friedman and Amnon Hizi and Dror Avni and Mary Bakhanashvili",
note = "Publisher Copyright: {\textcopyright} 2021",
year = "2021",
month = may,
doi = "10.1016/j.mito.2021.03.007",
language = "אנגלית",
volume = "58",
pages = "200--212",
journal = "Mitochondrion",
issn = "1567-7249",
publisher = "Elsevier",
}