TY - JOUR
T1 - MITF
T2 - master regulator of melanocyte development and melanoma oncogene
AU - Levy, Carmit
AU - Khaled, Mehdi
AU - Fisher, David E.
PY - 2006/9
Y1 - 2006/9
N2 - Microphthalmia-associated transcription factor (MITF) acts as a master regulator of melanocyte development, function and survival by modulating various differentiation and cell-cycle progression genes. It has been demonstrated that MITF is an amplified oncogene in a fraction of human melanomas and that it also has an oncogenic role in human clear cell sarcoma. However, MITF also modulates the state of melanocyte differentiation. Several closely related transcription factors also function as translocated oncogenes in various human malignancies. These data place MITF between instructing melanocytes towards terminal differentiation and/or pigmentation and, alternatively, promoting malignant behavior. In this review, we survey the roles of MITF as a master lineage regulator in melanocyte development and its emerging activities in malignancy. Understanding the molecular function of MITF and its associated pathways will hopefully shed light on strategies for improving therapeutic approaches for these diseases.
AB - Microphthalmia-associated transcription factor (MITF) acts as a master regulator of melanocyte development, function and survival by modulating various differentiation and cell-cycle progression genes. It has been demonstrated that MITF is an amplified oncogene in a fraction of human melanomas and that it also has an oncogenic role in human clear cell sarcoma. However, MITF also modulates the state of melanocyte differentiation. Several closely related transcription factors also function as translocated oncogenes in various human malignancies. These data place MITF between instructing melanocytes towards terminal differentiation and/or pigmentation and, alternatively, promoting malignant behavior. In this review, we survey the roles of MITF as a master lineage regulator in melanocyte development and its emerging activities in malignancy. Understanding the molecular function of MITF and its associated pathways will hopefully shed light on strategies for improving therapeutic approaches for these diseases.
UR - http://www.scopus.com/inward/record.url?scp=33747882661&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2006.07.008
DO - 10.1016/j.molmed.2006.07.008
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C2 - 16899407
AN - SCOPUS:33747882661
SN - 1471-4914
VL - 12
SP - 406
EP - 414
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 9
ER -
