MiRviewer: A multispecies microRNA homologous viewer

Adam Kiezun, Shay Artzi, Shira Modai, Naama Volk, Ofer Isakov, Noam Shomron*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Background: MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression via binding to the 3′ ends of mRNAs. MiRNAs have been associated with many cellular events ascertaining their central role in gene regulation. In order to better understand miRNAs of interest it is of utmost importance to learn about the genomic conservation of these genes. Findings. The miRviewer web-server, presented here, encompasses all known miRNAs of currently fully annotated animal genomes in a visual 'birds-eye' view representation. miRviewer provides a graphical outlook of the current miRNA world together with sequence alignments and secondary structures of each miRNA. As a test case we experimentally examined the expression of several miRNAs in various animals. Conclusions: miRviewer completes the homologous miRNA space with hundreds of unreported miRNAs and is available at:.

Original languageEnglish
Article number92
JournalBMC Research Notes
Volume5
DOIs
StatePublished - 2012

Funding

FundersFunder number
Kurz-Lion Foundation
Wolfson Family Charitable Fund
Chief Scientist Office
Israel Cancer Association
Israel Science Foundation41/11
Ministry of Health, State of Israel
Planning and Budgeting Committee of the Council for Higher Education of Israel

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