MiRviewer: A multispecies microRNA homologous viewer

Adam Kiezun; Shay Artzi; Shira Modai; Naama Volk; Ofer Isakov; Noam Shomron

doi:10.1186/1756-0500-5-92

MiRviewer: A multispecies microRNA homologous viewer

Adam Kiezun, Shay Artzi, Shira Modai, Naama Volk, Ofer Isakov, Noam Shomron^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Background: MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression via binding to the 3′ ends of mRNAs. MiRNAs have been associated with many cellular events ascertaining their central role in gene regulation. In order to better understand miRNAs of interest it is of utmost importance to learn about the genomic conservation of these genes. Findings. The miRviewer web-server, presented here, encompasses all known miRNAs of currently fully annotated animal genomes in a visual 'birds-eye' view representation. miRviewer provides a graphical outlook of the current miRNA world together with sequence alignments and secondary structures of each miRNA. As a test case we experimentally examined the expression of several miRNAs in various animals. Conclusions: miRviewer completes the homologous miRNA space with hundreds of unreported miRNAs and is available at:.

Original language	English
Article number	92
Journal	BMC Research Notes
Volume	5
DOIs	https://doi.org/10.1186/1756-0500-5-92
State	Published - 2012

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title = "MiRviewer: A multispecies microRNA homologous viewer",

abstract = "Background: MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression via binding to the 3′ ends of mRNAs. MiRNAs have been associated with many cellular events ascertaining their central role in gene regulation. In order to better understand miRNAs of interest it is of utmost importance to learn about the genomic conservation of these genes. Findings. The miRviewer web-server, presented here, encompasses all known miRNAs of currently fully annotated animal genomes in a visual 'birds-eye' view representation. miRviewer provides a graphical outlook of the current miRNA world together with sequence alignments and secondary structures of each miRNA. As a test case we experimentally examined the expression of several miRNAs in various animals. Conclusions: miRviewer completes the homologous miRNA space with hundreds of unreported miRNAs and is available at:.",

author = "Adam Kiezun and Shay Artzi and Shira Modai and Naama Volk and Ofer Isakov and Noam Shomron",

note = "Funding Information: Work in the Shomron laboratory is supported by the Chief Scientist Office, Ministry of Health, Israel; The Kurz-Lion Foundation; Israel Cancer Association; Ori Levy Foundation for Mitochondrial Research; The Wolfson Family Charitable Fund. This research was also supported by the I-CORE Program of the Planning and Budgeting Committee and The Israel Science Foundation (grant number 41/11). OI is supported by the Safra Bioinformatics Fellowship.",

year = "2012",

doi = "10.1186/1756-0500-5-92",

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T2 - A multispecies microRNA homologous viewer

AU - Kiezun, Adam

AU - Artzi, Shay

AU - Modai, Shira

AU - Volk, Naama

AU - Isakov, Ofer

AU - Shomron, Noam

N1 - Funding Information: Work in the Shomron laboratory is supported by the Chief Scientist Office, Ministry of Health, Israel; The Kurz-Lion Foundation; Israel Cancer Association; Ori Levy Foundation for Mitochondrial Research; The Wolfson Family Charitable Fund. This research was also supported by the I-CORE Program of the Planning and Budgeting Committee and The Israel Science Foundation (grant number 41/11). OI is supported by the Safra Bioinformatics Fellowship.

PY - 2012

Y1 - 2012

N2 - Background: MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression via binding to the 3′ ends of mRNAs. MiRNAs have been associated with many cellular events ascertaining their central role in gene regulation. In order to better understand miRNAs of interest it is of utmost importance to learn about the genomic conservation of these genes. Findings. The miRviewer web-server, presented here, encompasses all known miRNAs of currently fully annotated animal genomes in a visual 'birds-eye' view representation. miRviewer provides a graphical outlook of the current miRNA world together with sequence alignments and secondary structures of each miRNA. As a test case we experimentally examined the expression of several miRNAs in various animals. Conclusions: miRviewer completes the homologous miRNA space with hundreds of unreported miRNAs and is available at:.

AB - Background: MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression via binding to the 3′ ends of mRNAs. MiRNAs have been associated with many cellular events ascertaining their central role in gene regulation. In order to better understand miRNAs of interest it is of utmost importance to learn about the genomic conservation of these genes. Findings. The miRviewer web-server, presented here, encompasses all known miRNAs of currently fully annotated animal genomes in a visual 'birds-eye' view representation. miRviewer provides a graphical outlook of the current miRNA world together with sequence alignments and secondary structures of each miRNA. As a test case we experimentally examined the expression of several miRNAs in various animals. Conclusions: miRviewer completes the homologous miRNA space with hundreds of unreported miRNAs and is available at:.

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MiRviewer: A multispecies microRNA homologous viewer

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