miRNAkey: A software for microRNA deep sequencing analysis

Roy Ronen, Ido Gan, Shira Modai, Alona Sukacheov, Gideon Dror, Eran Halperin, Noam Shomron*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Motivation: MicroRNAs (miRNAs) are short abundant non-coding RNAs critical for many cellular processes. Deep sequencing (next-generation sequencing) technologies are being readily used to receive a more accurate depiction of miRNA expression profiles in living cells. This type of analysis is a key step towards improving our understanding of the complexity and mode of miRNA regulation.Results: miRNAkey is a software package designed to be used as a base-station for the analysis of miRNA deep sequencing data. The package implements common steps taken in the analysis of such data, as well as adds unique features, such as data statistics and multiple read determination, generating a novel platform for the analysis of miRNA expression. A user-friendly graphical interface is applied to determine the analysis steps. The tabular and graphical output contains general and detailed reports on the sequence reads and provides an accurate picture of the differentially expressed miRNAs in paired samples.

Original languageEnglish
Article numberbtq493
Pages (from-to)2615-2616
Number of pages2
JournalBioinformatics
Volume26
Issue number20
DOIs
StatePublished - 27 Aug 2010

Funding

FundersFunder number
Kurz-Lion Foundation
Schreiber Foundation
Wolfson Family Charitable Fund
National Science FoundationIIS-071325412
Israel Science Foundation04514831
Tel Aviv University
Ministry of Health, State of Israel

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