TY - JOUR
T1 - MiRNA-124a
T2 - a Potential Biomarker for Neurological Deficits Following Cardiac Surgery in Pediatric Patients
AU - Zloto, Keren
AU - Mor, Liat
AU - Bar-Yosef, Omer
AU - Tirosh-Wagner, Tal
AU - Vardi, Amir
AU - Mishali, David
AU - Paret, Gideon
AU - Nevo-Caspi, Yael
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/12
Y1 - 2021/12
N2 - Brain injury is a major source of patient morbidity after cardiac surgery in children. New early accurate biomarkers are needed for the diagnosis of patients at risk for cerebral postoperative damage. Specific circulating miRNAs have been found as suitable biomarkers for many diseases. We tested whether miRNA-124a reflects neurological injury in pediatric patients following heart surgery. Serum samples were obtained from 34 patients before and six hours after heart surgery. MiRNAs-124a was quantified by RQ-PCR. MiRNA-124a levels six hours after heart surgery correlated with the neurological outcome of the patients. In children with neurological deficits, miRNA-124a levels increased while in those with no neurological deficits the levels decreased. MiRNA-124a was able, at six hours after the operation, to identify patients who are at risk for the appearance of neurological deficits. Circulating miRNA-124a is a potential biomarker for the appearance of neurological deficits in pediatric patients following heart surgery. [Figure not available: see fulltext.].
AB - Brain injury is a major source of patient morbidity after cardiac surgery in children. New early accurate biomarkers are needed for the diagnosis of patients at risk for cerebral postoperative damage. Specific circulating miRNAs have been found as suitable biomarkers for many diseases. We tested whether miRNA-124a reflects neurological injury in pediatric patients following heart surgery. Serum samples were obtained from 34 patients before and six hours after heart surgery. MiRNAs-124a was quantified by RQ-PCR. MiRNA-124a levels six hours after heart surgery correlated with the neurological outcome of the patients. In children with neurological deficits, miRNA-124a levels increased while in those with no neurological deficits the levels decreased. MiRNA-124a was able, at six hours after the operation, to identify patients who are at risk for the appearance of neurological deficits. Circulating miRNA-124a is a potential biomarker for the appearance of neurological deficits in pediatric patients following heart surgery. [Figure not available: see fulltext.].
KW - Biomarker
KW - Congenital heart disease
KW - MiRNA
KW - MiRNA-124a
KW - Neurological deficit
KW - Pediatric cardiac surgery
UR - http://www.scopus.com/inward/record.url?scp=85104838528&partnerID=8YFLogxK
U2 - 10.1007/s12265-021-10127-7
DO - 10.1007/s12265-021-10127-7
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C2 - 33900534
AN - SCOPUS:85104838528
SN - 1937-5387
VL - 14
SP - 1165
EP - 1172
JO - Journal of Cardiovascular Translational Research
JF - Journal of Cardiovascular Translational Research
IS - 6
ER -
