@article{4a24cbdf360141e6b4322547fdf5284c,
title = "Mirabazoles, minor tantazole-related cytotoxins from the terrestrial blue-green alga scytonema mirabile",
abstract = "Three tantazole-related compounds, viz. didehydromirabazole A (1) and mirabazoles B (2) and C (3), have been isolated as minor components from Scytonema mirabile (Dillwyn) Bornet (strain BY-8-1) and their structures elucidated.",
author = "Shmuel Carmeli and Moore, {Richard E.} and Patterson, {Gregory L.}",
note = "Funding Information: Mirabazole C (3), m/z 424.0876 (talc. for C,aH24N4S4, 0.7 mmu error), shows a similar lHNMR spectrumI to that of 2. In the spectrumo f 3, however, the signal for the methyl on C-4 of thiazole ring D is missing. Instead there is a 1H doublet at 7.76 ppm (H-4 on ring D) which shows coupling (3.3 Hz) with the a 1H doublet at 7.23 ppm (H-5 on ring D); the chemical shifts of these two protons and the small coupling constant are in agreement with a P-substitutedt hiarole.B Moreover, the chemical shifts and couplings for the protons in rings A-C are essentially identical with those reported for tantazole F (8) .3 At this writing nothing is known about the relative and absolute stereochemistryo f 1 -3. Acknowledgments. This research was supported by Grant No. CA12623 from the National Cancer Institute,D epartmento f Health and Human Services. The 500 MHz nmr spectrometert hat was used in this study was purchased with a grant from the National Science Foundation. The authors thank Drs. Thomas Corbett and Frederick Valeriote (Wayne State University School of Medicine) for evaluating 1 for selective cytotoxicity.",
year = "1991",
month = jun,
day = "3",
doi = "10.1016/S0040-4039(00)78793-4",
language = "אנגלית",
volume = "32",
pages = "2593--2596",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd.",
number = "23",
}