MiR-125 in normal and malignant hematopoiesis

L. Shaham, V. Binder, N. Gefen, A. Borkhardt, S. Izraeli*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

MiR-125 is a highly conserved microRNA throughout many different species from nematode to humans. In humans, there are three homologs (hsa-miR-125b-1, hsa-miR-125b-2 and hsa-miR-125a). Here we review a recent research on the role of miR-125 in normal and malignant hematopoietic cells. Its high expression in hematopoietic stem cells (HSCs) enhances self-renewal and survival. Its expression in specific subtypes of myeloid and lymphoid leukemias provides resistance to apoptosis and blocks further differentiation. A direct oncogenic role in the hematopoietic system has recently been demonstrated by several mouse models. Targets of miR-125b include key proteins regulating apoptosis, innate immunity, inflammation and hematopoietic differentiation.

Original languageEnglish
Pages (from-to)2011-2018
Number of pages8
JournalLeukemia
Volume26
Issue number9
DOIs
StatePublished - Sep 2012

Keywords

  • acute lymphoblastic leukemia
  • acute myeloid leukemia
  • hematological malignancies
  • hematopoiesis
  • microRNA

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