TY - JOUR
T1 - Minor Clinical Impact of COVID-19 Pandemic on Patients With Primary Immunodeficiency in Israel
AU - Marcus, Nufar
AU - Frizinsky, Shirly
AU - Hagin, David
AU - Ovadia, Adi
AU - Hanna, Suhair
AU - Farkash, Michael
AU - Maoz-Segal, Ramit
AU - Agmon-Levin, Nancy
AU - Broides, Arnon
AU - Nahum, Amit
AU - Rosenberg, Elli
AU - Kuperman, Amir Asher
AU - Dinur-Schejter, Yael
AU - Berkun, Yackov
AU - Toker, Ori
AU - Goldberg, Shmuel
AU - Confino-Cohen, Ronit
AU - Scheuerman, Oded
AU - Badarneh, Basel
AU - Epstein-Rigbi, Na‘ama
AU - Etzioni, Amos
AU - Dalal, Ilan
AU - Somech, Raz
N1 - Publisher Copyright:
© Copyright © 2021 Marcus, Frizinsky, Hagin, Ovadia, Hanna, Farkash, Maoz-Segal, Agmon-Levin, Broides, Nahum, Rosenberg, Kuperman, Dinur-Schejter, Berkun, Toker, Goldberg, Confino-Cohen, Scheuerman, Badarneh, Epstein-Rigbi, Etzioni, Dalal and Somech.
PY - 2021/1/14
Y1 - 2021/1/14
N2 - In the last few months the world has witnessed a global pandemic due to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection causing coronavirus disease 2019 (COVID-19). Obviously, this pandemic affected individuals differently, with a significant impact on populations considered to be at high-risk. One such population, was assumed to be patients with primary genetic defect involving components or pathways of the immune system. While human immunity against COVID-19 is not fully understood, it is, so far, well documented, that both adaptive and innate cells have a critical role in protection against SARS-CoV-2. Here, we aimed to summarize the clinical and laboratory data on primary immunodeficiency (PID) patients in Israel, who were tested positive for SARS-CoV-2, in order to estimate the impact of COVID-19 on such patients. Data was collected from mid-February to end-September. During this time Israel experienced two “waves” of COVID-19 diseases; the first, from mid-February to mid-May and the second from mid-June and still ongoing at the end of data collection. A total of 20 PID patients, aged 4 months to 60 years, were tested positive for SARS-CoV-2, all but one, were detected during the second wave. Fourteen of the patients were on routine monthly IVIG replacement therapy at the time of virus detection. None of the patients displayed severe illness and none required hospitalization; moreover, 7/20 patients were completely asymptomatic. Possible explanations for the minimal clinical impact of COVID-19 pandemic observed in our PID patients include high level of awareness, extra-precautions, and even self-isolation. It is also possible that only specific immune pathways (e.g. type I interferon signaling), may increase the risk for a more severe course of disease and these are not affected in many of the PID patients. In some cases, lack of an immune response actually may be a protective measure against the development of COVID-19 sequelae.
AB - In the last few months the world has witnessed a global pandemic due to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection causing coronavirus disease 2019 (COVID-19). Obviously, this pandemic affected individuals differently, with a significant impact on populations considered to be at high-risk. One such population, was assumed to be patients with primary genetic defect involving components or pathways of the immune system. While human immunity against COVID-19 is not fully understood, it is, so far, well documented, that both adaptive and innate cells have a critical role in protection against SARS-CoV-2. Here, we aimed to summarize the clinical and laboratory data on primary immunodeficiency (PID) patients in Israel, who were tested positive for SARS-CoV-2, in order to estimate the impact of COVID-19 on such patients. Data was collected from mid-February to end-September. During this time Israel experienced two “waves” of COVID-19 diseases; the first, from mid-February to mid-May and the second from mid-June and still ongoing at the end of data collection. A total of 20 PID patients, aged 4 months to 60 years, were tested positive for SARS-CoV-2, all but one, were detected during the second wave. Fourteen of the patients were on routine monthly IVIG replacement therapy at the time of virus detection. None of the patients displayed severe illness and none required hospitalization; moreover, 7/20 patients were completely asymptomatic. Possible explanations for the minimal clinical impact of COVID-19 pandemic observed in our PID patients include high level of awareness, extra-precautions, and even self-isolation. It is also possible that only specific immune pathways (e.g. type I interferon signaling), may increase the risk for a more severe course of disease and these are not affected in many of the PID patients. In some cases, lack of an immune response actually may be a protective measure against the development of COVID-19 sequelae.
KW - COVID-19
KW - SARS-CoV-2
KW - agammaglobulinemia
KW - coronavirus disease 2019
KW - inborn errors of immunity
KW - pandemic
KW - primary immunodeficiency
KW - severe acute respiratory syndrome-coronavirus-2
UR - http://www.scopus.com/inward/record.url?scp=85100109445&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2020.614086
DO - 10.3389/fimmu.2020.614086
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 33519822
AN - SCOPUS:85100109445
SN - 1664-3224
VL - 11
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 614086
ER -