Minocycline-induced cutaneous hyperpigmentation: Confocal laser scanning microscope analysis

R. P. Dodiuk-Gad, H. M. de Morentin, J. Schafer, A. Harel, M. Neudorfer, F. Misonzhnik, G. Gitstein, D. Rozenman, E. Tur, S. Brenner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Background: Minocycline has a characteristic yellow-green fluorescent emission. This fluorescence has been previously demonstrated only in type 1 minocycline-induced skin hyperpigmentation. Objective: To investigate whether the fluorescence can be detected in other types of minocycline-induced cutaneous hyperpigmentation, and to study the possible mechanisms. Methods: Biopsies of pigmented and nonpigmented skin from 3 patients with different types of skin hyperpigmentation induced by minocycline were analysed by light microscopy and Confocal Laser Scanning Microscope (CLSM). Results: A yellow-green fluorescence was observed in the hyperpigmented skin of two patients with type 2, and one patient with type 4 minocycline-induced cutaneous hyperpigmentation. No fluorescence was detected in the non-pigmented skin. Conclusion: Minocycline can possibly serve as a fluorescent probe in the diagnosis of all types of minocycline-induced cutaneous hyperpigmentation.

Original languageEnglish
Pages (from-to)435-439
Number of pages5
JournalJournal of the European Academy of Dermatology and Venereology
Issue number4
StatePublished - Apr 2006


  • Confocal microscope
  • Fluorescence
  • Hyperpigmentation
  • Minocycline


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