Minocycline-induced cutaneous hyperpigmentation: Confocal laser scanning microscope analysis

R. P. Dodiuk-Gad; H. M. de Morentin; J. Schafer; A. Harel; M. Neudorfer; F. Misonzhnik; G. Gitstein; D. Rozenman; E. Tur; S. Brenner

doi:10.1111/j.1468-3083.2006.01436.x

Minocycline-induced cutaneous hyperpigmentation: Confocal laser scanning microscope analysis

R. P. Dodiuk-Gad, H. M. de Morentin, J. Schafer, A. Harel, M. Neudorfer, F. Misonzhnik, G. Gitstein, D. Rozenman, E. Tur, S. Brenner^*

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Minocycline has a characteristic yellow-green fluorescent emission. This fluorescence has been previously demonstrated only in type 1 minocycline-induced skin hyperpigmentation. Objective: To investigate whether the fluorescence can be detected in other types of minocycline-induced cutaneous hyperpigmentation, and to study the possible mechanisms. Methods: Biopsies of pigmented and nonpigmented skin from 3 patients with different types of skin hyperpigmentation induced by minocycline were analysed by light microscopy and Confocal Laser Scanning Microscope (CLSM). Results: A yellow-green fluorescence was observed in the hyperpigmented skin of two patients with type 2, and one patient with type 4 minocycline-induced cutaneous hyperpigmentation. No fluorescence was detected in the non-pigmented skin. Conclusion: Minocycline can possibly serve as a fluorescent probe in the diagnosis of all types of minocycline-induced cutaneous hyperpigmentation.

Original language	English
Pages (from-to)	435-439
Number of pages	5
Journal	Journal of the European Academy of Dermatology and Venereology
Volume	20
Issue number	4
DOIs	https://doi.org/10.1111/j.1468-3083.2006.01436.x
State	Published - Apr 2006

Keywords

Confocal microscope
Fluorescence
Hyperpigmentation
Minocycline

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10.1111/j.1468-3083.2006.01436.x

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Dodiuk-Gad, R. P., de Morentin, H. M., Schafer, J., Harel, A., Neudorfer, M., Misonzhnik, F., Gitstein, G., Rozenman, D., Tur, E., & Brenner, S. (2006). Minocycline-induced cutaneous hyperpigmentation: Confocal laser scanning microscope analysis. Journal of the European Academy of Dermatology and Venereology, 20(4), 435-439. https://doi.org/10.1111/j.1468-3083.2006.01436.x

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title = "Minocycline-induced cutaneous hyperpigmentation: Confocal laser scanning microscope analysis",

abstract = "Background: Minocycline has a characteristic yellow-green fluorescent emission. This fluorescence has been previously demonstrated only in type 1 minocycline-induced skin hyperpigmentation. Objective: To investigate whether the fluorescence can be detected in other types of minocycline-induced cutaneous hyperpigmentation, and to study the possible mechanisms. Methods: Biopsies of pigmented and nonpigmented skin from 3 patients with different types of skin hyperpigmentation induced by minocycline were analysed by light microscopy and Confocal Laser Scanning Microscope (CLSM). Results: A yellow-green fluorescence was observed in the hyperpigmented skin of two patients with type 2, and one patient with type 4 minocycline-induced cutaneous hyperpigmentation. No fluorescence was detected in the non-pigmented skin. Conclusion: Minocycline can possibly serve as a fluorescent probe in the diagnosis of all types of minocycline-induced cutaneous hyperpigmentation.",

keywords = "Confocal microscope, Fluorescence, Hyperpigmentation, Minocycline",

author = "Dodiuk-Gad, {R. P.} and {de Morentin}, {H. M.} and J. Schafer and A. Harel and M. Neudorfer and F. Misonzhnik and G. Gitstein and D. Rozenman and E. Tur and S. Brenner",

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doi = "10.1111/j.1468-3083.2006.01436.x",

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Dodiuk-Gad, RP, de Morentin, HM, Schafer, J, Harel, A, Neudorfer, M, Misonzhnik, F, Gitstein, G, Rozenman, D, Tur, E & Brenner, S 2006, 'Minocycline-induced cutaneous hyperpigmentation: Confocal laser scanning microscope analysis', Journal of the European Academy of Dermatology and Venereology, vol. 20, no. 4, pp. 435-439. https://doi.org/10.1111/j.1468-3083.2006.01436.x

TY - JOUR

T1 - Minocycline-induced cutaneous hyperpigmentation

T2 - Confocal laser scanning microscope analysis

AU - Dodiuk-Gad, R. P.

AU - de Morentin, H. M.

AU - Schafer, J.

AU - Harel, A.

AU - Neudorfer, M.

AU - Misonzhnik, F.

AU - Gitstein, G.

AU - Rozenman, D.

AU - Tur, E.

AU - Brenner, S.

PY - 2006/4

Y1 - 2006/4

N2 - Background: Minocycline has a characteristic yellow-green fluorescent emission. This fluorescence has been previously demonstrated only in type 1 minocycline-induced skin hyperpigmentation. Objective: To investigate whether the fluorescence can be detected in other types of minocycline-induced cutaneous hyperpigmentation, and to study the possible mechanisms. Methods: Biopsies of pigmented and nonpigmented skin from 3 patients with different types of skin hyperpigmentation induced by minocycline were analysed by light microscopy and Confocal Laser Scanning Microscope (CLSM). Results: A yellow-green fluorescence was observed in the hyperpigmented skin of two patients with type 2, and one patient with type 4 minocycline-induced cutaneous hyperpigmentation. No fluorescence was detected in the non-pigmented skin. Conclusion: Minocycline can possibly serve as a fluorescent probe in the diagnosis of all types of minocycline-induced cutaneous hyperpigmentation.

AB - Background: Minocycline has a characteristic yellow-green fluorescent emission. This fluorescence has been previously demonstrated only in type 1 minocycline-induced skin hyperpigmentation. Objective: To investigate whether the fluorescence can be detected in other types of minocycline-induced cutaneous hyperpigmentation, and to study the possible mechanisms. Methods: Biopsies of pigmented and nonpigmented skin from 3 patients with different types of skin hyperpigmentation induced by minocycline were analysed by light microscopy and Confocal Laser Scanning Microscope (CLSM). Results: A yellow-green fluorescence was observed in the hyperpigmented skin of two patients with type 2, and one patient with type 4 minocycline-induced cutaneous hyperpigmentation. No fluorescence was detected in the non-pigmented skin. Conclusion: Minocycline can possibly serve as a fluorescent probe in the diagnosis of all types of minocycline-induced cutaneous hyperpigmentation.

KW - Confocal microscope

KW - Fluorescence

KW - Hyperpigmentation

KW - Minocycline

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Minocycline-induced cutaneous hyperpigmentation: Confocal laser scanning microscope analysis

Abstract

Keywords

UN SDGs

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