Minimal traumatic brain injury induce apoptotic cell death in mice

V. Tashlykov, Y. Katz, A. Volkov, V. Gazit, S. Schreiber, O. Zohar, C. G. Pick

Research output: Contribution to journalArticlepeer-review

Abstract

In the United States, 1.4 million people suffer from traumatic brain injury (TBI) each year because of traffic, sports, or war-related injuries. The majority of TBI victims suffer mild to minimal TBI (mTBI), but most are released undiagnosed. Detailed pathologies are poorly understood. We characterized the microscopic changes of neurons of closed-head mTBI mice after increased unilateral trauma using hematoxylin and eosin (H&E) stain, and correlated it with the expression of the apoptotic proteins c-jun, p53, and BCL-2. Minimal damage to the brain increases the number of pyknotic appearing neurons and activates the apoptotic proteins in both hemispheres. Although minimal, increased impact was positively correlated with the increased number of damaged neurons. These results may explain the wide variety of behavioral and cognitive deficits closed-head mTBI causes in mice. Our cumulative results point to the pathological origin of post-concussion syndrome and may aid in the development of future neuroprotective strategies for the disease.

Original languageEnglish
Pages (from-to)16-24
Number of pages9
JournalJournal of Molecular Neuroscience
Volume37
Issue number1
DOIs
StatePublished - Jan 2009

Keywords

  • Apoptosis
  • Bcl-2
  • C-jun
  • H & E
  • Mice
  • Minimal TBI
  • P53

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