TY - JOUR
T1 - Mind your left
T2 - Spatial bias in subcortical fear processing
AU - Siman-Tov, Tali
AU - Papo, David
AU - Gadoth, Natan
AU - Schonberg, Tom
AU - Mendelsohn, Avi
AU - Perry, Daniella
AU - Hendler, Talma
N1 - Funding Information:
This work was supported by the Israel Science Foundation, Bikura program (T. H.), the Binational Science Foundation (T. H.), and the Israel Ministry of Science, Culture & Sport, Merkava program (T. H.). We thank Dr. Yulia Lerner, Ilana Podlipsky, Ronit Libling, Dr. Hadas Okon-Singer, Keren Rosenberg, Dr. Irit Lichter-Shapira, Dr. Galia Avidan, Dr. Galit Yovel, Ayelet Yokev, and Oren Levin for technical and data analysis assistance, as well as Esther Eshkol and Frances Zetland for helpful comments on the manuscript. We especially thank Prof. Leslie Ungerleider for her valuable contribution to the study design and for helpful discussions and critiques.
PY - 2009/9
Y1 - 2009/9
N2 - Hemispheric lateralization of emotional processing has long been suggested, but its underlying neural mechanisms have not yet been defined. In this functional magnetic resonance imaging study, facial expressions were presented to 10 right-handed healthy adult females in an event-related visual halffield presentation paradigm. Differential activations to fearful versus neutral faces were observed in the amygdala, pulvinar, and superior colliculus only for faces presented in the left hemifield. Interestingly, the left hemifield advantage for fear processing was observed in both hemispheres. These results suggest a leftward bias in subcortical fear processing, consistent with the well-documented leftward bias of danger-associated behaviors in animals. The current finding highlights the importance of hemifield advantage in emotional lateralization, which might reflect the combination of hemispheric dominance and asymmetric interhemispheric information transfer.
AB - Hemispheric lateralization of emotional processing has long been suggested, but its underlying neural mechanisms have not yet been defined. In this functional magnetic resonance imaging study, facial expressions were presented to 10 right-handed healthy adult females in an event-related visual halffield presentation paradigm. Differential activations to fearful versus neutral faces were observed in the amygdala, pulvinar, and superior colliculus only for faces presented in the left hemifield. Interestingly, the left hemifield advantage for fear processing was observed in both hemispheres. These results suggest a leftward bias in subcortical fear processing, consistent with the well-documented leftward bias of danger-associated behaviors in animals. The current finding highlights the importance of hemifield advantage in emotional lateralization, which might reflect the combination of hemispheric dominance and asymmetric interhemispheric information transfer.
UR - http://www.scopus.com/inward/record.url?scp=67650450483&partnerID=8YFLogxK
U2 - 10.1162/jocn.2009.21120
DO - 10.1162/jocn.2009.21120
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AN - SCOPUS:67650450483
SN - 0898-929X
VL - 21
SP - 1782
EP - 1789
JO - Journal of Cognitive Neuroscience
JF - Journal of Cognitive Neuroscience
IS - 9
ER -