MinD-RNase E interplay controls localization of polar mRNAs in E. coli

Shanmugapriya Kannaiah*, Omer Goldberger, Nawsad Alam, Georgina Barnabas, Yair Pozniak, Anat Nussbaum-Shochat, Ora Schueler-Furman, Tamar Geiger, Orna Amster-Choder*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


(Figure presented.) A subset of E. coli transcripts localizes to the cell poles via an unknown mechanism. Here, the interaction of MinD and RNase E is shown to prevent site-specific degradation of polar mRNAs, thus favoring their enrichment in the cell poles. Candidate approach and proteomic analysis identify MinD and RNase E as regulators of polar mRNA localization. MinD interacts with a short peptide within the membrane-targeting sequence of RNase E. In the absence of MinD, RNase E transiently accumulates at cell poles. Polar accumulation of RNase E in ΔminCDE cells destabilizes polar mRNAs, resulting in their elimination from the poles and potentially affecting localization of the encoded proteins.

Original languageEnglish
Pages (from-to)637-662
Number of pages26
JournalEMBO Journal
Issue number4
StatePublished - 15 Feb 2024


FundersFunder number
Israel Academy of Sciences and Humanities1274/19, 301/2021
Israel Science Foundation


    • Bacterial Cell Organization
    • Bacterial Cell Poles
    • MinD
    • RNA Localization
    • RNase E


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