Migratory ichthyosiform dermatosis with type 2 diabetes mellitus and insulin resistance

Gil Yosipovitch*, Baruch Mevorah, Michael David, Maora Feinmesser, Emmilia Hodak, Boaz Gabay, Jamal Ammash, Peter M. Elias

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: In addition to the well-defined hereditary primary ichthyoses, many sporadic or less well-defined keratinization disorders with or without systemic manifestations have been reported. Herein we describe ichthyosiform dermatosis associated with type 2 diabetes mellitus. Observations: The patients were members of a large Arab family with heavy consanguinity. Eighteen members were affected with a variously severe scaly disorder. They showed migratory polycyclic keratotic scaly plaques evolving into diffuse generalized scaling or complete remission. Acanthosis nigricans- like lesions were also noted, and there was an association with type 2 diabetes mellitus. A scarcity of intercorneocyte lamellae and reduction in lamellar body contents were observed. Conclusions: We could not find a report of a similar dermatosis. Furthermore, an association between ichthyosis and diabetes has not been documented. Therefore, we believe that this may constitute a new entity.

Original languageEnglish
Pages (from-to)1237-1242
Number of pages6
JournalArchives of Dermatology
Volume135
Issue number10
DOIs
StatePublished - Oct 1999
Externally publishedYes

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