Midtrimester triple-test levels in women with chronic hypertension and altered renal function

Simon Shenhavl, Ofer Gemer, Dan J. Sherman, Ronit Peled, Shmuel Segal

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To study the association between midtrimester triple-test levels and renal function in pregnant women with chronic hypertension. Methods: Forty-three patients with chronic hypertension for whom renal function was evaluated by the creatinine clearance test between 14- and 20-weeks gestation were studied. Midtrimester triple-test values obtained as part of Down screening program were correlated with renal function. Results hCG correlated inversely with creatinine clearance (r = -0.345; p = 0.002) and directly with alpha-fetoprotein (r = 0.499; p = 0.003). Conclusions: In pregnant women with chronic hypertension, impaired renal function may alter midtrimester maternal serum hCG levels.

Original languageEnglish
Pages (from-to)166-167
Number of pages2
JournalPrenatal Diagnosis
Volume23
Issue number2
DOIs
StatePublished - 1 Feb 2003
Externally publishedYes

Keywords

  • Chronic hypertension
  • Midtrimester triple test
  • Renal function

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