Midtrimester induction of abortion: Comparison of extraovular prostaglandin E2 and intra-amniotic prostaglandin F2α

Samuel Lurie; Zvi Katz; Vaclav Insler

doi:10.1016/0010-7824(93)90099-S

Midtrimester induction of abortion: Comparison of extraovular prostaglandin E2 and intra-amniotic prostaglandin F2α

Samuel Lurie^*, Zvi Katz, Vaclav Insler

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The efficacy of extraovular prostaglandin E₂ and intra-amniotic prostaglandin F_2α for pregnancy termination in midtrimester was compared. A retrospective review of pregnancy termination in midtrimester using intra-amniotic instillation of 40 mg of prostaglandin F_2α (n = 133) or extraovular instillation of prostaglandin E₂ at a rate of 500 μg/hour (n = 81) was performed. Both groups had a similar mean induction-to-abortion interval (19.5 ± 19.9 and 20.9 ± 18.2 hours for extraovular PGE₂ and intra-amniotic PGF_2α, respectively) and a similar success rate ot abortion within the first 24 hours of initial treatment (84.0% for extraovular PGE₂ and 76.7% for intra-amniotic PGF_2α). The two groups had a similar and low (9.8%) incidence of complications. It is concluded that either of the methods used in the study (i.e. extraovular PGE₂ or intra-amniotic PGF_2α) can be used safely and effectively for pregnancy termination in midtrimester.

Original language	English
Pages (from-to)	475-481
Number of pages	7
Journal	Contraception
Volume	47
Issue number	5
DOIs	https://doi.org/10.1016/0010-7824(93)90099-S
State	Published - May 1993
Externally published	Yes

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@article{5884926e324e46d79b7396afbe0920f0,

title = "Midtrimester induction of abortion: Comparison of extraovular prostaglandin E2 and intra-amniotic prostaglandin F2α",

abstract = "The efficacy of extraovular prostaglandin E2 and intra-amniotic prostaglandin F2α for pregnancy termination in midtrimester was compared. A retrospective review of pregnancy termination in midtrimester using intra-amniotic instillation of 40 mg of prostaglandin F2α (n = 133) or extraovular instillation of prostaglandin E2 at a rate of 500 μg/hour (n = 81) was performed. Both groups had a similar mean induction-to-abortion interval (19.5 ± 19.9 and 20.9 ± 18.2 hours for extraovular PGE2 and intra-amniotic PGF2α, respectively) and a similar success rate ot abortion within the first 24 hours of initial treatment (84.0% for extraovular PGE2 and 76.7% for intra-amniotic PGF2α). The two groups had a similar and low (9.8%) incidence of complications. It is concluded that either of the methods used in the study (i.e. extraovular PGE2 or intra-amniotic PGF2α) can be used safely and effectively for pregnancy termination in midtrimester.",

author = "Samuel Lurie and Zvi Katz and Vaclav Insler",

year = "1993",

month = may,

doi = "10.1016/0010-7824(93)90099-S",

language = "אנגלית",

volume = "47",

pages = "475--481",

journal = "Contraception",

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T2 - Comparison of extraovular prostaglandin E2 and intra-amniotic prostaglandin F2α

AU - Lurie, Samuel

AU - Katz, Zvi

AU - Insler, Vaclav

PY - 1993/5

Y1 - 1993/5

N2 - The efficacy of extraovular prostaglandin E2 and intra-amniotic prostaglandin F2α for pregnancy termination in midtrimester was compared. A retrospective review of pregnancy termination in midtrimester using intra-amniotic instillation of 40 mg of prostaglandin F2α (n = 133) or extraovular instillation of prostaglandin E2 at a rate of 500 μg/hour (n = 81) was performed. Both groups had a similar mean induction-to-abortion interval (19.5 ± 19.9 and 20.9 ± 18.2 hours for extraovular PGE2 and intra-amniotic PGF2α, respectively) and a similar success rate ot abortion within the first 24 hours of initial treatment (84.0% for extraovular PGE2 and 76.7% for intra-amniotic PGF2α). The two groups had a similar and low (9.8%) incidence of complications. It is concluded that either of the methods used in the study (i.e. extraovular PGE2 or intra-amniotic PGF2α) can be used safely and effectively for pregnancy termination in midtrimester.

AB - The efficacy of extraovular prostaglandin E2 and intra-amniotic prostaglandin F2α for pregnancy termination in midtrimester was compared. A retrospective review of pregnancy termination in midtrimester using intra-amniotic instillation of 40 mg of prostaglandin F2α (n = 133) or extraovular instillation of prostaglandin E2 at a rate of 500 μg/hour (n = 81) was performed. Both groups had a similar mean induction-to-abortion interval (19.5 ± 19.9 and 20.9 ± 18.2 hours for extraovular PGE2 and intra-amniotic PGF2α, respectively) and a similar success rate ot abortion within the first 24 hours of initial treatment (84.0% for extraovular PGE2 and 76.7% for intra-amniotic PGF2α). The two groups had a similar and low (9.8%) incidence of complications. It is concluded that either of the methods used in the study (i.e. extraovular PGE2 or intra-amniotic PGF2α) can be used safely and effectively for pregnancy termination in midtrimester.

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ER -

Midtrimester induction of abortion: Comparison of extraovular prostaglandin E2 and intra-amniotic prostaglandin F2α

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