TY - JOUR
T1 - Microvessels in chronic total occlusions
T2 - Pathways for successful guidewire crossing?
AU - Strauss, Bradley H.
AU - Segev, Amit
AU - Wright, Graham A.
AU - Qiang, Beiping
AU - Munce, Nigel
AU - Anderson, Kevan J.T.
AU - Leung, General
AU - Dick, Alexander J.
AU - Virmani, Renu
AU - Butany, Jagdish
PY - 2005/12
Y1 - 2005/12
N2 - Arterial chronic total occlusions (CTO) are a common and clinically relevant problem in patients with coronary artery disease. Percutaneous coronary intervention (PCI) success rates in a wide range of CTO are low, primarily due to inability of guidewire crossing. The pathophysiology of CTO is poorly understood and limits our ability to introduce innovative therapies. Recent studies from our laboratory have suggested that microvessel formation within arterial CTO is a complex process with temporal and regional differences. Moreover, there is evidence from pilot studies that the presence of either microvessels or the particular extracellular matrix environment in the adjacent perivascular tissue can facilitate guidewire crossing and successful PCL Currently, studies are underway in our experimental CTO model to delineate the pathophysiology of microvessel formation in CTO and its potential role in PCI.
AB - Arterial chronic total occlusions (CTO) are a common and clinically relevant problem in patients with coronary artery disease. Percutaneous coronary intervention (PCI) success rates in a wide range of CTO are low, primarily due to inability of guidewire crossing. The pathophysiology of CTO is poorly understood and limits our ability to introduce innovative therapies. Recent studies from our laboratory have suggested that microvessel formation within arterial CTO is a complex process with temporal and regional differences. Moreover, there is evidence from pilot studies that the presence of either microvessels or the particular extracellular matrix environment in the adjacent perivascular tissue can facilitate guidewire crossing and successful PCL Currently, studies are underway in our experimental CTO model to delineate the pathophysiology of microvessel formation in CTO and its potential role in PCI.
UR - http://www.scopus.com/inward/record.url?scp=28444440923&partnerID=8YFLogxK
U2 - 10.1111/j.1540-8183.2005.00082.x
DO - 10.1111/j.1540-8183.2005.00082.x
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C2 - 16336422
AN - SCOPUS:28444440923
VL - 18
SP - 425
EP - 436
JO - Journal of Interventional Cardiology
JF - Journal of Interventional Cardiology
SN - 0896-4327
IS - 6
ER -