@article{6b3ed18704ce4c8dbe0bec61299c4c17,
title = "Microtubule-stabilizing peptides and small molecules protecting axonal transport and brain function: Focus on davunetide (NAP)",
abstract = "This review focuses on the therapeutic effects and mechanisms of action of NAP (davunetide), an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP) which was discovered in our laboratory. We have recently described the effects of NAP in neurodegenerative disorders, and we now review the beneficial effects of NAP and other microtubule-stabilizing agents on impairments in axonal transport. Experiments in animal models of microtubule-deficiency including tauopathy (spanning from drosophila to mammals) showed protection of axonal transport by microtubule-stabilizers and NAP, which was coupled to motor and cognitive protection. Clinical trials with NAP (davunetide) are reviewed paving the path to future developments.",
keywords = "Activity-dependent neuroprotective protein (ADNP), Axonal transport, Davunetide, NAP, Neurodegenerative diseases, Neurological disorders",
author = "Iddo Magen and Illana Gozes",
note = "Funding Information: Dr. Iddo Magen was partially supported by a Post-Doctoral Fellowship from Tel Aviv University . The laboratory of Professor Illana Gozes (the Lily and Avraham Gildor Chair for the Investigation of Growth Factors and Director of the Adams Super Center for Brain Studies at Tel Aviv University ) was supported by the AMN Foundation , CFTAU Montreal Circle of Friends , Barbara and Don Seal , the Oberfeld and the Adams families , Adams Super Center for Brain Studies and at Tel Aviv University and the Dr. Diana and Zelman Elton (Elbaum) Laboratory for Molecular Neuroendocrinology . Allon Therapeutics Inc. has been developing davunetide (NAP) and related compounds. Professor Gozes is a Humboldt Award Recipient, a fellow at Hanse-Wissenschftenkolleg, Germany. ",
year = "2013",
month = dec,
doi = "10.1016/j.npep.2013.10.011",
language = "אנגלית",
volume = "47",
pages = "489--495",
journal = "Neuropeptides",
issn = "0143-4179",
publisher = "Churchill Livingstone",
number = "6",
}