TY - JOUR
T1 - Microsphere intestinal blood flow analysis during pneumoperitoneum using carbon dioxide and helium
AU - Goitein, D.
AU - Papasavas, P.
AU - Yeaney, W.
AU - Gagne, D.
AU - Hayetian, F.
AU - Caushaj, P.
AU - Keenan, R.
AU - Landreneau, R.
PY - 2005/4
Y1 - 2005/4
N2 - Background: Pneumoperitoneum has been associated with a decreased flow in the superior mesenteric artery and portal venous system. Intestinal blood flow was studied during a 2-h pneumoperitoneum with carbon dioxide (CO2) or helium in a porcine model using colored microspheres. Methods: For this study, 12 pigs were divided into two groups (6 CO2 and 6 helium). Different colored microspheres were injected directly into the left ventricle before, 40, 80, and 120 min after insufflation with either gas at a pressure of 15 mmHg. Microsphere concentration was measured in the mucosa and muscularis/serosa layers of the jejunum, cecum, and sigmoid colon to calculate blood flow. Results: Intestinal perfusion initially increases with insufflation and returns to near baseline levels during pneumoperitoneum of 2 h. The effect of helium on tissue perfusion is similar to that of carbon dioxide. Conclusions: Intestinal perfusion does not change significantly during prolonged pneumoperitoneum at a pressure of 15 mmHg with CO2 or helium.
AB - Background: Pneumoperitoneum has been associated with a decreased flow in the superior mesenteric artery and portal venous system. Intestinal blood flow was studied during a 2-h pneumoperitoneum with carbon dioxide (CO2) or helium in a porcine model using colored microspheres. Methods: For this study, 12 pigs were divided into two groups (6 CO2 and 6 helium). Different colored microspheres were injected directly into the left ventricle before, 40, 80, and 120 min after insufflation with either gas at a pressure of 15 mmHg. Microsphere concentration was measured in the mucosa and muscularis/serosa layers of the jejunum, cecum, and sigmoid colon to calculate blood flow. Results: Intestinal perfusion initially increases with insufflation and returns to near baseline levels during pneumoperitoneum of 2 h. The effect of helium on tissue perfusion is similar to that of carbon dioxide. Conclusions: Intestinal perfusion does not change significantly during prolonged pneumoperitoneum at a pressure of 15 mmHg with CO2 or helium.
KW - Intestinal perfusion
KW - Microspheres
KW - Pneumoperitoneum
UR - http://www.scopus.com/inward/record.url?scp=21244440733&partnerID=8YFLogxK
U2 - 10.1007/s00464-004-8911-0
DO - 10.1007/s00464-004-8911-0
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C2 - 15742125
AN - SCOPUS:21244440733
SN - 0930-2794
VL - 19
SP - 541
EP - 545
JO - Surgical Endoscopy and Other Interventional Techniques
JF - Surgical Endoscopy and Other Interventional Techniques
IS - 4
ER -