TY - JOUR
T1 - Microscale Rockets and Picoliter Containers Engineered from Electrospun Polymeric Microtubes
AU - Sitt, Amit
AU - Soukupova, Jana
AU - Miller, David
AU - Verdi, David
AU - Zboril, Radek
AU - Hess, Henry
AU - Lahann, Joerg
N1 - Funding Information:
This work was supported by the Defense Threat Reduction Agency under award numbers HDTRA 1-12-1-0037 and HDTRA 1-12-1-0039. A.S. gratefully acknowledges a Fulbright scholarship (United States-Israel Educational Foundation) and a Raymond and Beverly Sackler fellowship for their support. J.S. gratefully acknowledges the support by the project LO1305 of the Ministry of Education, Youth and Sports of the Czech Republic, and the Operational Program "Education for Competitiveness-European Social Fund" CZ.1.07/2.3.00/20.0056 of the Ministry of Education, Youth and Sports of the Czech Republic. The fi nancial support from the Technology Agency of the Czech Republic "Competence Centres" (project TE02000006) is acknowledged.
PY - 2016/3
Y1 - 2016/3
N2 - The fabrication of biocompatible and biodegradable hollow microcylinders is reported. The hollow microcylinders, made of poly (lactic-co-glycolic acid) (PLGA) and polyethylene oxide (PEO), are obtained by coelectrospinning, followed by a cryosectioning step to prepare microtubes with defined aspect ratios. The obtained microtubes maintain their coaxial compartmentalization, which allows for selective chemical modification of the luminal walls either via chemical reactions or via physical adsorption of proteins. The control over the inner surface chemistry allows for binding of different markers specifi cally to the cavity walls using a variety of chemical reactions, and to adsorb enzymes and metallic nanoparticles (MNPs), which can support catalytic reactions inside the cavity. Coupling electrospun fibers with MNPs holds high promise for different applications including antimicrobial agents, charge collection media, and catalysis.
AB - The fabrication of biocompatible and biodegradable hollow microcylinders is reported. The hollow microcylinders, made of poly (lactic-co-glycolic acid) (PLGA) and polyethylene oxide (PEO), are obtained by coelectrospinning, followed by a cryosectioning step to prepare microtubes with defined aspect ratios. The obtained microtubes maintain their coaxial compartmentalization, which allows for selective chemical modification of the luminal walls either via chemical reactions or via physical adsorption of proteins. The control over the inner surface chemistry allows for binding of different markers specifi cally to the cavity walls using a variety of chemical reactions, and to adsorb enzymes and metallic nanoparticles (MNPs), which can support catalytic reactions inside the cavity. Coupling electrospun fibers with MNPs holds high promise for different applications including antimicrobial agents, charge collection media, and catalysis.
KW - biodegradable polymers
KW - catalytic micromotors
KW - electrospinning
KW - microcontainers
KW - microtubes
UR - http://www.scopus.com/inward/record.url?scp=84960377517&partnerID=8YFLogxK
U2 - 10.1002/smll.201503467
DO - 10.1002/smll.201503467
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C2 - 26797691
AN - SCOPUS:84960377517
SN - 1613-6810
VL - 12
SP - 1432
EP - 1439
JO - Small
JF - Small
IS - 11
ER -