microRNAs: The art of silencing in the ear

Anya Rudnicki, Karen B. Avraham*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression through the RNA interference (RNAi) pathway and by inhibition of mRNA translation. miRNAs first made their appearance in the auditory and vestibular systems in 2005, with the discovery of a triad of hair cell-specific miRNAs later found to be involved in both human and mouse deafness. Since then, miRNAs have been implicated in other medical conditions related to these systems, such as cholesteatomas, vestibular schwannomas and otitis media. Due to the limitations in studying miRNAs and their targets derived from human inner ears, animal models are vital in this field of research. Therefore their role in inner ear development and function has been demonstrated by studies in zebrafish and mice. Transcriptomic and proteomic approaches have been undertaken to identify miRNAs and their targets. Finally, it has been suggested that miRNAs may be used in the future in regeneration of inner ear hair cells and ultimately play a role in therapeutics.

Original languageEnglish
Pages (from-to)849-859
Number of pages11
JournalEMBO Molecular Medicine
Issue number9
StatePublished - Sep 2012


  • Auditory
  • Cochlea
  • Deafness
  • Mice
  • Vestibule


Dive into the research topics of 'microRNAs: The art of silencing in the ear'. Together they form a unique fingerprint.

Cite this