@article{d011bd33d75241a0819731743eb5e2a7,
title = "MicroRNA miR-125a-3p modulates molecular pathway of motility and migration in prostate cancer cells",
abstract = "Fyn kinase is implicated in prostate cancer. We illustrate the role of miR-125a- 3p in cellular pathways accounted for motility and migration of prostate cancer cells, probably through its regulation on Fyn expression and Fyn-downstream proteins. Prostate cancer PC3 cells were transiently transfected with empty miR-Vec (control) or with miR-125a-3p. Overexpression of miR-125a-3p reduced migration of PC3 cells and increased apoptosis. Live cell confocal imaging indicated that overexpression of miR-125a-3p reduced the cells' track speed and length and impaired phenotype. Fyn, FAK and paxillin, displayed reduced activity following miR-125a-3p overexpression. Accordingly, actin rearrangement and cells' protrusion formation were impaired. An inverse correlation between miR-125a-3p and Gleason score was observed in human prostate cancer tissues. Our study demonstrated that miR-125a-3p may regulate migration of prostate cancer cells.",
keywords = "Actin cytoskeleton, EMT, Fyn, Live imaging, MiR-125a-3p, Migration, Prostate cancer",
author = "Lihi Ninio-Many and Hadas Grossman and Mattan Levi and Sofia Zilber and Ilan Tsarfaty and Noam Shomron and Anna Tuvar and Dana Chuderland and Stemmer, {Salomon M.} and Irit Ben-Aharon and Ruth Shalgi",
note = "Funding Information: This work was supported by a grant from the Israel Science Foundation [grant number 261/09 to R.S.].",
year = "2014",
doi = "10.18632/oncoscience.29",
language = "אנגלית",
volume = "1",
pages = "250--261",
journal = "Oncoscience",
issn = "2331-4737",
publisher = "Impact Journals LLC",
number = "4",
}
