Micropeptins from Microcystis sp. collected in Kabul Reservoir, Israel

Tanja Thorskov Bladt, Sivan Kalifa-Aviv, Thomas Ostenfeld Larsen, Shmuel Carmeli*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Three new micropeptins, micropeptin KR1030, KR1002 and KR998 and the known microcyclamide GL546A were isolated from the extract of Microcystis sp. bloom material collected in Kabul Reservoir, Israel. The planar structures of the compounds were determined by homonuclear and inverse-heteronuclear 2D-NMR techniques as well as high-resolution mass spectrometry. The absolute configuration of the asymmetric centres of the amino acids was studied using Marfey's method for HPLC. The inhibitory activity of the compounds was determined for the serine proteases: trypsin, chymotrypsin and elastase.

Original languageEnglish
Pages (from-to)936-943
Number of pages8
JournalTetrahedron
Volume70
Issue number4
DOIs
StatePublished - 28 Jan 2014

Funding

FundersFunder number
Israel Science Foundation776/06
Otto Mønsteds Fond

    Keywords

    • Cyanobacteria
    • Microcystis
    • Micropeptins
    • Natural products
    • Protease inhibitors

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