Microparticles, thrombosis and cancer

Anat Aharon, Benjamin Brenner

Research output: Contribution to journalReview articlepeer-review

Abstract

Microvesicles comprised of exosomes and microparticles are shed from both normal and malignant cells upon cell activation or apoptosis. Microvesicles promote clot formation, mediate pro-inflammatory processes, facilitate cell-to-cell interactions, transfer proteins and mRNA to cells, and induce cell signalling. Microparticles bearing tissue factor play a central role in coagulation initiation and thrombus formation. This chapter will review earlier studies which focus on the role of procoagulant microvesicles in cancer thrombogenicity, and discuss the effects of microvesicles on vascular cell dysfunction and angiogenesis. In addition, this chapter will present new findings which characterize the haemostatic balance of microparticles, and suggest a method that may potentially serve to predict a state of hypercoagulability in cancer patients. This chapter highlights the interplay between microvesicles, coagulation factors and cancer.

Original languageEnglish
Pages (from-to)61-69
Number of pages9
JournalBest Practice and Research in Clinical Haematology
Volume22
Issue number1
DOIs
StatePublished - Mar 2009
Externally publishedYes

Keywords

  • angiogenesis
  • cancer
  • microparticles
  • microvesicles
  • thrombosis
  • tissue factor

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