Microheterogeneities, non-equivalence, and embryonic induction

J. W. Lash, M. Ovadia, N. S. Vasan

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The thrust of this report is to stress the importance of microheterogeneities in the microenvironment of differentiating tissues as a possible inducer or regulator of differentiation. During chondrogenesis both qualitative and quantitative changes occur in the proteoglycan population. Using molecular sieve chromatography, these changes can be characterized and used as indices of differentiation. Microheterogeneities of the extracellular matrix may be an example of 'non equivalence' as a regulatory device for differentiation.

Original languageEnglish
Pages (from-to)333-338
Number of pages6
JournalMedical Biology
Issue number6
StatePublished - 1978
Externally publishedYes


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