Microbiome sharing between children, livestock and household surfaces in western Kenya

Emily Mosites; Matt Sammons; Elkanah Otiang; Alexander Eng; Cecilia Noecker; Ohad Manor; Sarah Hilton; Samuel M. Thumbi; Clayton Onyango; Gemina Garland-Lewis; Douglas R. Call; M. Kariuki Njenga; Judith N. Wasserheit; Jennifer A. Zambriski; Judd L. Walson; Guy H. Palmer; Joel Montgomery; Elhanan Borenstein; Richard Omore; Peter M. Rabinowitz

doi:10.1371/journal.pone.0171017

Microbiome sharing between children, livestock and household surfaces in western Kenya

Emily Mosites, Matt Sammons, Elkanah Otiang, Alexander Eng, Cecilia Noecker, Ohad Manor, Sarah Hilton, Samuel M. Thumbi, Clayton Onyango, Gemina Garland-Lewis, Douglas R. Call, M. Kariuki Njenga, Judith N. Wasserheit, Jennifer A. Zambriski, Judd L. Walson, Guy H. Palmer, Joel Montgomery, Elhanan Borenstein, Richard Omore, Peter M. Rabinowitz

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

The gut microbiome community structure and development are associated with several health outcomes in young children. To determine the household influences of gut microbiome structure, we assessed microbial sharing within households in western Kenya by sequencing 16S rRNA libraries of fecal samples from children and cattle, cloacal swabs from chickens, and swabs of household surfaces. Among the 156 households studied, children within the same household significantly shared their gut microbiome with each other, although we did not find significant sharing of gut microbiome across host species or household surfaces. Higher gut microbiome diversity among children was associated with lower wealth status and involvement in livestock feeding chores. Although more research is necessary to identify further drivers of microbiota development, these results suggest that the household should be considered as a unit. Livestock activities, health and microbiome perturbations among an individual child may have implications for other children in the household.

Original language	English
Article number	e0171017
Journal	PLoS ONE
Volume	12
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0171017
State	Published - Feb 2017
Externally published	Yes

Funding

Funders	Funder number
National Institute of Allergy and Infectious Diseases	T32AI007025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0171017

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Mosites, E., Sammons, M., Otiang, E., Eng, A., Noecker, C., Manor, O., Hilton, S., Thumbi, S. M., Onyango, C., Garland-Lewis, G., Call, D. R., Njenga, M. K., Wasserheit, J. N., Zambriski, J. A., Walson, J. L., Palmer, G. H., Montgomery, J., Borenstein, E., Omore, R., & Rabinowitz, P. M. (2017). Microbiome sharing between children, livestock and household surfaces in western Kenya. PLoS ONE, 12(2), Article e0171017. https://doi.org/10.1371/journal.pone.0171017

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abstract = "The gut microbiome community structure and development are associated with several health outcomes in young children. To determine the household influences of gut microbiome structure, we assessed microbial sharing within households in western Kenya by sequencing 16S rRNA libraries of fecal samples from children and cattle, cloacal swabs from chickens, and swabs of household surfaces. Among the 156 households studied, children within the same household significantly shared their gut microbiome with each other, although we did not find significant sharing of gut microbiome across host species or household surfaces. Higher gut microbiome diversity among children was associated with lower wealth status and involvement in livestock feeding chores. Although more research is necessary to identify further drivers of microbiota development, these results suggest that the household should be considered as a unit. Livestock activities, health and microbiome perturbations among an individual child may have implications for other children in the household.",

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note = "Publisher Copyright: {\textcopyright} This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.",

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Mosites, E, Sammons, M, Otiang, E, Eng, A, Noecker, C, Manor, O, Hilton, S, Thumbi, SM, Onyango, C, Garland-Lewis, G, Call, DR, Njenga, MK, Wasserheit, JN, Zambriski, JA, Walson, JL, Palmer, GH, Montgomery, J, Borenstein, E, Omore, R & Rabinowitz, PM 2017, 'Microbiome sharing between children, livestock and household surfaces in western Kenya', PLoS ONE, vol. 12, no. 2, e0171017. https://doi.org/10.1371/journal.pone.0171017

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AU - Walson, Judd L.

AU - Palmer, Guy H.

AU - Montgomery, Joel

AU - Borenstein, Elhanan

AU - Omore, Richard

AU - Rabinowitz, Peter M.

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Y1 - 2017/2

N2 - The gut microbiome community structure and development are associated with several health outcomes in young children. To determine the household influences of gut microbiome structure, we assessed microbial sharing within households in western Kenya by sequencing 16S rRNA libraries of fecal samples from children and cattle, cloacal swabs from chickens, and swabs of household surfaces. Among the 156 households studied, children within the same household significantly shared their gut microbiome with each other, although we did not find significant sharing of gut microbiome across host species or household surfaces. Higher gut microbiome diversity among children was associated with lower wealth status and involvement in livestock feeding chores. Although more research is necessary to identify further drivers of microbiota development, these results suggest that the household should be considered as a unit. Livestock activities, health and microbiome perturbations among an individual child may have implications for other children in the household.

AB - The gut microbiome community structure and development are associated with several health outcomes in young children. To determine the household influences of gut microbiome structure, we assessed microbial sharing within households in western Kenya by sequencing 16S rRNA libraries of fecal samples from children and cattle, cloacal swabs from chickens, and swabs of household surfaces. Among the 156 households studied, children within the same household significantly shared their gut microbiome with each other, although we did not find significant sharing of gut microbiome across host species or household surfaces. Higher gut microbiome diversity among children was associated with lower wealth status and involvement in livestock feeding chores. Although more research is necessary to identify further drivers of microbiota development, these results suggest that the household should be considered as a unit. Livestock activities, health and microbiome perturbations among an individual child may have implications for other children in the household.

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Microbiome sharing between children, livestock and household surfaces in western Kenya

Abstract

Funding

UN SDGs

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