Microbial Prions: Dawn of a New Era

Shon A. Levkovich, Sigal Rencus-Lazar, Ehud Gazit, Dana Laor Bar-Yosef

Research output: Contribution to journalReview articlepeer-review


Protein misfolding and aggregation are associated with human diseases and aging. However, microorganisms widely exploit the self-propagating properties of misfolded infectious protein particles, prions, as epigenetic information carriers that drive various phenotypic adaptations and encode molecular information. Microbial prion research has faced a paradigm shift in recent years, with breakthroughs that demonstrate the great functional and structural diversity of these agents. Here, we outline unorthodox examples of microbial prions in yeast and other microorganisms, focusing on their noncanonical functions. We discuss novel molecular mechanisms for the inheritance of conformationally-encoded epigenetic information and the evolutionary advantages they confer. Lastly, in light of recent advancements in the field of molecular self-assembly, we present a hypothesis regarding the existence of non-proteinaceous prion-like entities.

Original languageEnglish
Pages (from-to)391-405
Number of pages15
JournalTrends in Biochemical Sciences
Issue number5
StatePublished - May 2021


  • amyloids
  • metions
  • microorganisms
  • prions
  • self-assembly


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