Microarray studies of prognostic stratification and transformation of follicular lymphomas

Shaklai Sigal, Amariglio Ninette, Gideon Rechavi

Research output: Contribution to journalReview articlepeer-review

Abstract

Follicular lymphoma (FL) is a common, indolent malignancy with a natural history of transformation to the more aggressive form of diffuse large B-cell lymphoma (DLBCL) in 25-60% of cases. In order to understand the pathogenesis of lymphoma genesis and evolution, the molecular changes characteristic of FL and transformed DLBCL are being studied. The most common abnormality associated with FL is the t(14;18)(q32;q21) chromosomal translocation, but many more molecular aberrations have been found in patient subgroups. The study of gene expression profiling using DNA microarrays enables large scale, comparative analyses of gene expression. Its implementation in the research on FL has led to advances in disease diagnosis and classification and has the potential to lead to pathogenesis-based individualised therapies.

Original languageEnglish
Pages (from-to)143-156
Number of pages14
JournalBest Practice and Research in Clinical Haematology
Volume18
Issue number1 SPEC. ISS.
DOIs
StatePublished - Mar 2005

Keywords

  • Follicular lymphoma
  • Microarray
  • Prognosis
  • Transformation

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