Microarchitecture of the augmented bone following sinus elevation with an albumin impregnated demineralized freeze-dried bone allograft (BoneAlbumin) versus anorganic bovine bone mineral: A randomized prospective clinical, histomorphometric, and micro-computed tomography study

Kivovics Márton, Szabó Bence Tamás, Németh Orsolya, Czinkóczky Béla, Dori Ferenc, Nagy Péter, Dobó Nagy Csaba, Csönge Lajos, Lacza Zsombor, Mijiritsky Eitan, Szabó György

Research output: Contribution to journalArticlepeer-review

Abstract

Serum albumin has been identified as an endogenous protein that is integral to early bone regeneration. We hypothesized that albumin addition to allografts may result in better bone remodeling than what can be achieved with anorganic xenografts. Sinus elevations were performed at 32 sites of 18 patients with the lateral window technique. Sites either received filling with an anorganic bovine bone mineral (ABBM, BioOss, Geistlich, CH) or albumin impregnated allograft (BoneAlbumin, OrthoSera, AT). After 6-months patients received dental implants and 16 bone core biopsy samples were obtained from the ABBM filled, and 16 from the BoneAlbumin augmented sites. The biopsies were examined by histomorphometry and μCT. Percentage of the residual graft in the BoneAlbumin group was 0-12.7%, median 5.4% vs. ABBM 6.3-35.9%, median 16.9%, p < 0.05. Results of the μCT analysis showed that the microarchitecture of the augmented bone in the BoneAlbumin group resembles that of the native maxilla in morphometric parameters Trabecular Pattern Factor and Connectivity. Our data show that while ABBM successfully integrates into the newly formed bone tissue as persisting particles, BoneAlbumin is underway towards complete remodeling with new bone closely resembling that of the intact maxilla.

Original languageEnglish
Article number202
JournalMaterials
Volume11
Issue number2
DOIs
StatePublished - 28 Jan 2018

Keywords

  • Allograft
  • Bone graft material
  • Histology
  • Histomorphometry
  • Maxillary sinus floor augmentation
  • X-ray microtomography
  • Xenograft

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