Micro-organ ovarian transplantation enables pregnancy: A case report

Ariel Revel*, Neri Laufer, Assaf Ben Meir, Meital Lebovich, Eduardo Mitrani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A 19-year-old thalassemic woman had tissue from one of her ovaries cryopreserved prior to bone marrow transplantation, total body irradiation and sterilizing chemotherapy. As expected, premature ovarian failure resulted from this treatment. Transplantation of her thawed ovarian tissue resulted in return of menstrual cycling and the patient then underwent several IVF cycles. The patient, however, had poor ovarian response to hyperstimulation. We thus considered an alternative approach based on the observation that very thin ovarian fragments that preserve the basic ovarian structure [ovarian micro-organs (MOs)] induce angiogenesis and remained viable after autologous transplantation in animals. We report that preparation of autologous tiny ovarian fragments (MO)s and reimplantation into our patient resulted in IVF pregnancy and delivery of a healthy baby.

Original languageEnglish
Pages (from-to)1097-1103
Number of pages7
JournalHuman Reproduction
Issue number5
StatePublished - May 2011
Externally publishedYes


  • avascular transplantation
  • cryopreservation
  • micro-organs
  • ovarian transplantation
  • thalassemia


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