Micro-inflammatory changes in asymptomatic healthy adults during bouts of respiratory tract infections in the community: Potential triggers for atherothrombotic events

Arie Steinvil, Shlomo Berliner, Michal Bromberg, Michael Cohen, Varda Shalev, Itzhak Shapira, Ori Rogowski

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To explore the possibility that mild inflammatory changes exist in asymptomatic adults during bouts of acute respiratory tract infections in the general population, and may mediate atherothrombotic events. Methods: An epidemiological study that enrolled 5315 males and 2795 females attending a routine screening health program between the years 2003 and 2007. We correlated the concentrations of high sensitivity C-reactive protein (hs-CRP) and quantitative fibrinogen in completely asymptomatic and non-inflamed adults to the weekly epidemiological data for the incidence of acute respiratory tract infections in the community. Results: Significant seasonal variations in the inflammatory variables were found for both genders. The population's weekly rates of acute respiratory tract infection had a significant epidemiological influence on the inflammatory biomarkers in the asymptomatic cohort. The magnitude of this influence could reach as much as 12% (3-22%) in hs-CRP concentrations in women and 0.30 μmol/L (0.20-0.41) in fibrinogen concentrations in men, for the change between the mean August and the mean January population's respiratory illness burden. Conclusion: Increase in the concentrations of two inflammation-sensitive biomarkers can occur in completely asymptomatic adults at times of increased burden of acute respiratory tract infection in the general population. The possibility exists that these inflammatory changes represent occult and asymptomatic infections that could by themselves trigger acute atherothrombotic events.

Original languageEnglish
Pages (from-to)270-275
Number of pages6
JournalAtherosclerosis
Volume206
Issue number1
DOIs
StatePublished - Sep 2009
Externally publishedYes

Keywords

  • Acute respiratory tract infection
  • Atherothrombotic events
  • C-reactive protein
  • Fibrinogen
  • Inflammation

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