Miconazole activity in experimental Aspergillus ocular infections

E. Segal, A. Romano, Y. R. Barishak

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The in vitro and in vivo activity of miconazole in Aspergillus ocular infections was studied. The in vitro susceptibility to miconazole of stock cultures of 5 pathogenic Aspergillus species and of 10 aspergillus strains isolated from human ocular infections was assayed, revealing that the Aspergillus strains were sensitive in vitro to miconazole. The in vivo activity of miconazole was assayed in 45 rabbits with experimental A. fumigatus ocular infections, which were treated with miconazole, administered topically and/or systemically, to test the drug's capability to cure or prevent infections. Neither the topical nor the systemic nor combined treatments resulted in a cure or significant improvement of the severe ocular infections. However, infections could be prevented by pretreatment with miconazole prior to infection or treatment together with the inoculation of the infective agent.

Original languageEnglish
Pages (from-to)12-19
Number of pages8
JournalOphthalmic Research
Issue number1
StatePublished - 1981


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